| 2020-11-25 | @ | Oakland | W | 101-49 | |
| 2020-11-26 | @ | Bradley | W | 51-50 | |
| 2020-11-27 | @ | Toledo | W | 76-73 | |
| 2020-11-30 | @ | Eastern Ky. | W | 99-96 | OT |
| 2020-12-02 | @ | Tennessee Tech | W | 79-48 | |
| 2020-12-06 | vs. | Cincinnati | W | 69-77 | |
| 2020-12-09 | @ | Oklahoma | W | 99-77 | |
| 2020-12-20 | @ | Marquette | W | 91-88 | |
| 2020-12-23 | vs. | Creighton | L | 66-61 | |
| 2020-12-30 | @ | Seton Hall | L | 68-85 | |
| 2021-01-06 | @ | St. John's (NY) | W | 69-61 | |
| 2021-01-10 | @ | Providence | W | 74-73 | |
| 2021-01-30 | vs. | Butler | W | 55-68 | |
| 2021-02-13 | @ | UConn | L | 72-80 | |
| 2021-02-16 | vs. | St. John's (NY) | L | 93-84 | |
| 2021-02-21 | @ | Butler | W | 63-51 | |
| 2021-02-24 | vs. | Providence | L | 83-68 | |
| 2021-02-27 | @ | Creighton | W | 77-69 | |
| 2021-03-02 | vs. | Georgetown | L | 72-66 | |
| 2021-03-06 | vs. | Marquette | L | 66-59 | |
| 2021-03-10 | @ | Butler | L | 69-70 | OT |