| 2020-11-25 | @ | Eastern Ill. | W | 77-67 | |
| 2020-11-27 | @ | Ark.-Pine Bluff | W | 92-58 | |
| 2020-12-01 | @ | Green Bay | W | 82-42 | |
| 2020-12-04 | vs. | Marquette | L | 67-65 | |
| 2020-12-09 | @ | Rhode Island | W | 73-62 | |
| 2020-12-15 | @ | Loyola Chicago | W | 77-63 | |
| 2020-12-19 | @ | Louisville | W | 85-48 | |
| 2020-12-22 | @ | Nebraska | W | 67-53 | |
| 2020-12-25 | vs. | Michigan St. | W | 76-85 | |
| 2020-12-28 | @ | Maryland | L | 64-70 | |
| 2020-12-31 | @ | Minnesota | W | 71-59 | |
| 2021-01-07 | @ | Indiana | W | 80-73 | 2OT |
| 2021-01-12 | vs. | Michigan | L | 77-54 | |
| 2021-01-15 | vs. | Rutgers | W | 54-60 | |
| 2021-01-20 | @ | Northwestern | W | 68-52 | |
| 2021-01-23 | @ | Ohio St. | L | 62-74 | |
| 2021-01-27 | vs. | Maryland | W | 55-61 | |
| 2021-01-30 | vs. | Penn St. | L | 81-71 | |
| 2021-02-02 | @ | Penn St. | W | 72-56 | |
| 2021-02-06 | vs. | Illinois | L | 75-60 | |
| 2021-02-10 | vs. | Nebraska | W | 48-61 | |
| 2021-02-14 | @ | Michigan | L | 59-67 | |
| 2021-02-18 | @ | Iowa | L | 62-77 | |
| 2021-02-21 | vs. | Northwestern | W | 51-68 | |
| 2021-02-27 | @ | Illinois | L | 69-74 | |
| 2021-03-02 | vs. | Purdue | L | 73-69 | |
| 2021-03-07 | vs. | Iowa | L | 77-73 | |
| 2021-03-11 | @ | Penn St. | W | 75-74 | |
| 2021-03-12 | vs. | Iowa | L | 62-57 | |
| 2021-03-19 | vs. | North Carolina | W | 62-85 | |
| 2021-03-21 | vs. | Baylor | L | 76-63 |