| 2020-11-25 | @ | Eastern Ill. | W | 77-67 | |
| 2020-11-27 | @ | Ark.-Pine Bluff | W | 92-58 | |
| 2020-12-01 | @ | Green Bay | W | 82-42 | |
| 2020-12-04 | vs. | Marquette | L | 67-65 | |
| 2020-12-09 | @ | Rhode Island | W | 73-62 | |
| 2020-12-15 | @ | Loyola Chicago | W | 77-63 | |
| 2020-12-19 | @ | Louisville | W | 85-48 | |
| 2020-12-22 | @ | Nebraska | W | 67-53 | |
| 2020-12-25 | vs. | Michigan St. | W | 76-85 | |
| 2020-12-28 | @ | Maryland | L | 64-70 | |
| 2020-12-31 | @ | Minnesota | W | 71-59 | |
| 2021-01-07 | @ | Indiana | W | 80-73 | 2OT |
| 2021-01-12 | vs. | Michigan | L | 77-54 | |
| 2021-01-15 | vs. | Rutgers | W | 54-60 | |
| 2021-01-20 | @ | Northwestern | |||
| 2021-01-23 | @ | Ohio St. | |||
| 2021-01-27 | vs. | Penn St. | |||
| 2021-01-30 | vs. | Maryland | |||
| 2021-02-02 | @ | Penn St. | |||
| 2021-02-06 | vs. | Illinois | |||
| 2021-02-11 | vs. | Nebraska |