| 2020-12-02 | @ | Oral Roberts | W | 85-80 | |
| 2020-12-06 | @ | Missouri | L | 62-72 | |
| 2020-12-12 | @ | Oklahoma St. | L | 64-67 | |
| 2020-12-15 | vs. | Tulsa | W | 65-69 | |
| 2020-12-22 | vs. | South Fla. | W | 77-82 | OT |
| 2021-01-02 | vs. | Ole Miss | W | 79-83 | |
| 2021-01-06 | vs. | Houston | L | 70-63 | |
| 2021-01-10 | @ | Cincinnati | W | 82-76 | |
| 2021-01-13 | @ | Tulsa | W | 72-53 | |
| 2021-01-21 | vs. | Memphis | L | 72-52 | |
| 2021-01-30 | @ | UCF | W | 93-88 | OT |
| 2021-02-03 | @ | Tulane | W | 75-67 | |
| 2021-02-07 | @ | Temple | W | 70-67 | |
| 2021-02-10 | vs. | UCF | W | 60-61 | |
| 2021-02-18 | @ | Houston | W | 68-63 | |
| 2021-03-03 | vs. | Tulane | W | 70-78 | |
| 2021-03-06 | @ | South Fla. | W | 80-63 | |
| 2021-03-12 | @ | South Fla. | W | 68-67 | |
| 2021-03-18 | @ | Drake | L | 52-53 |