| 2020-11-25 | vs. | Butler | L | 66-62 | |
| 2020-12-06 | vs. | Michigan St. | L | 79-61 | |
| 2020-12-12 | @ | Detroit Mercy | L | 57-67 | |
| 2020-12-13 | @ | Milwaukee | L | 63-71 | |
| 2020-12-18 | @ | Central Mich. | W | 76-61 | |
| 2020-12-22 | @ | Ball St. | L | 68-76 | |
| 2021-01-02 | @ | Toledo | L | 59-70 | |
| 2021-01-09 | vs. | Kent St. | L | 80-54 | |
| 2021-01-12 | @ | Buffalo | L | 69-85 | |
| 2021-01-23 | @ | Akron | L | 68-79 | |
| 2021-01-26 | vs. | Ohio | L | 81-58 | |
| 2021-01-30 | vs. | Miami (OH) | L | 65-56 | |
| 2021-02-03 | vs. | Bowling Green | W | 70-76 | |
| 2021-02-06 | vs. | Central Mich. | W | 65-67 | |
| 2021-02-12 | vs. | Buffalo | L | 86-54 | |
| 2021-02-16 | @ | Kent St. | L | 69-76 | |
| 2021-02-25 | @ | Miami (OH) | L | 66-74 | |
| 2021-02-27 | vs. | Toledo | L | 91-44 | |
| 2021-03-02 | vs. | Northern Ill. | W | 63-73 | |
| 2021-03-05 | @ | Eastern Mich. | L | 63-64 |