| 2020-11-25 | @ | Delaware St. | W | 111-51 | |
| 2020-11-27 | @ | Longwood | W | 71-60 | |
| 2021-01-03 | vs. | Georgia Tech | L | 70-54 | |
| 2021-01-06 | vs. | Virginia | L | 70-61 | |
| 2021-01-09 | vs. | Duke | L | 79-68 | |
| 2021-01-13 | @ | Louisville | L | 65-77 | |
| 2021-01-17 | @ | Virginia Tech | L | 60-64 | |
| 2021-01-20 | vs. | North Carolina | L | 80-73 | |
| 2021-01-23 | @ | Pittsburgh | W | 76-75 | |
| 2021-01-27 | vs. | North Carolina St. | L | 72-67 | |
| 2021-01-30 | @ | Miami (FL) | W | 66-54 | |
| 2021-02-02 | vs. | Notre Dame | L | 79-58 | |
| 2021-02-10 | vs. | Boston College | W | 65-69 | |
| 2021-02-13 | vs. | Florida St. | L | 92-85 | OT |
| 2021-02-17 | @ | Duke | L | 60-84 | |
| 2021-02-20 | @ | North Carolina St. | L | 62-80 | |
| 2021-02-24 | @ | Clemson | L | 39-60 | |
| 2021-02-27 | vs. | Virginia Tech | L | 84-46 | |
| 2021-03-02 | vs. | Pittsburgh | L | 70-57 | |
| 2021-03-05 | @ | Georgia Tech | L | 63-75 | |
| 2021-03-09 | vs. | Notre Dame | L | 80-77 |