| 2020-11-25 | @ | Delaware St. | W | 111-51 | |
| 2020-11-27 | @ | Longwood | W | 71-60 | |
| 2021-01-03 | vs. | Georgia Tech | L | 70-54 | |
| 2021-01-06 | vs. | Virginia | L | 70-61 | |
| 2021-01-09 | vs. | Duke | L | 79-68 | |
| 2021-01-13 | @ | Louisville | L | 65-77 | |
| 2021-01-17 | @ | Virginia Tech | L | 60-64 | |
| 2021-01-20 | vs. | North Carolina | L | 80-73 | |
| 2021-01-23 | @ | Pittsburgh | |||
| 2021-01-27 | vs. | North Carolina St. | |||
| 2021-01-30 | @ | Miami (FL) | |||
| 2021-02-02 | vs. | Notre Dame | |||
| 2021-02-07 | @ | Pittsburgh | |||
| 2021-02-10 | vs. | Boston College |