| 2020-11-28 | vs. | Penn St. | L | 86-65 | |
| 2020-12-01 | @ | Longwood | W | 84-71 | |
| 2020-12-03 | vs. | Virginia Tech | L | 64-57 | |
| 2020-12-13 | @ | Hampton | W | 79-64 | |
| 2020-12-18 | vs. | Gardner-Webb | L | 88-77 | |
| 2020-12-21 | vs. | George Mason | L | 68-66 | |
| 2020-12-30 | vs. | Samford | L | 84-71 | |
| 2021-01-02 | @ | Chattanooga | W | 84-79 | |
| 2021-01-13 | @ | Wofford | L | 78-80 | |
| 2021-01-16 | @ | The Citadel | W | 110-103 | |
| 2021-01-18 | vs. | ETSU | L | 92-81 | |
| 2021-01-20 | @ | Furman | W | 74-73 | |
| 2021-01-23 | vs. | Mercer | L | 83-80 | |
| 2021-01-27 | @ | Western Caro. | W | 87-61 | |
| 2021-01-30 | vs. | UNCG | L | 76-59 | |
| 2021-02-03 | vs. | Wofford | W | 80-84 | OT |
| 2021-02-10 | vs. | Western Caro. | L | 74-72 | |
| 2021-02-13 | @ | Samford | W | 85-56 | |
| 2021-02-17 | @ | UNCG | W | 88-77 | |
| 2021-02-20 | vs. | The Citadel | L | 75-74 | |
| 2021-03-06 | vs. | Furman | W | 90-91 | OT |
| 2021-03-07 | @ | Mercer | L | 59-73 |