| 2020-11-25 | @ | Radford | W | 77-62 | |
| 2020-11-28 | vs. | Villanova | W | 73-81 | OT |
| 2020-11-29 | vs. | South Fla. | W | 58-76 | |
| 2020-12-03 | @ | VMI | W | 64-57 | |
| 2020-12-08 | @ | Penn St. | L | 55-75 | |
| 2020-12-15 | @ | Clemson | W | 66-60 | |
| 2020-12-19 | @ | Coppin St. | W | 97-57 | |
| 2020-12-21 | @ | Longwood | W | 84-58 | |
| 2020-12-29 | @ | Miami (FL) | W | 80-78 | |
| 2021-01-06 | vs. | Louisville | L | 73-71 | |
| 2021-01-10 | @ | Notre Dame | W | 77-63 | |
| 2021-01-12 | @ | Duke | W | 74-67 | |
| 2021-01-17 | vs. | Wake Forest | |||
| 2021-01-20 | @ | Boston College | |||
| 2021-01-23 | vs. | Syracuse | |||
| 2021-01-27 | vs. | Notre Dame | |||
| 2021-01-30 | @ | Virginia | |||
| 2021-02-03 | vs. | Pittsburgh | |||
| 2021-02-06 | vs. | Miami (FL) | |||
| 2021-02-09 | @ | Florida St. |