| 2020-11-25 | @ | Radford | W | 77-62 | |
| 2020-11-28 | vs. | Villanova | W | 73-81 | OT |
| 2020-11-29 | vs. | South Fla. | W | 58-76 | |
| 2020-12-03 | @ | VMI | W | 64-57 | |
| 2020-12-08 | @ | Penn St. | L | 55-75 | |
| 2020-12-15 | @ | Clemson | W | 66-60 | |
| 2020-12-19 | @ | Coppin St. | W | 97-57 | |
| 2020-12-21 | @ | Longwood | W | 84-58 | |
| 2020-12-29 | @ | Miami (FL) | W | 80-78 | |
| 2021-01-06 | vs. | Louisville | L | 73-71 | |
| 2021-01-10 | @ | Notre Dame | W | 77-63 | |
| 2021-01-12 | @ | Duke | W | 74-67 | |
| 2021-01-17 | vs. | Wake Forest | W | 60-64 | |
| 2021-01-23 | vs. | Syracuse | L | 78-60 | |
| 2021-01-27 | vs. | Notre Dame | W | 51-62 | |
| 2021-01-30 | @ | Virginia | W | 65-51 | |
| 2021-02-03 | vs. | Pittsburgh | L | 83-72 | |
| 2021-02-06 | vs. | Miami (FL) | W | 76-80 | OT |
| 2021-02-23 | @ | Georgia Tech | L | 53-69 | |
| 2021-02-27 | @ | Wake Forest | W | 84-46 | |
| 2021-03-11 | @ | North Carolina | L | 73-81 | |
| 2021-03-19 | vs. | Florida | L | 75-70 | OT |