| 2020-11-25 | vs. | Towson | W | 54-89 | |
| 2020-11-27 | vs. | San Francisco | L | 61-60 | |
| 2020-12-01 | @ | Saint Francis (PA) | W | 76-51 | |
| 2020-12-04 | @ | Kent St. | W | 71-64 | OT |
| 2020-12-22 | @ | William & Mary | W | 76-40 | |
| 2020-12-26 | vs. | Gonzaga | L | 98-75 | |
| 2020-12-30 | vs. | Notre Dame | W | 57-66 | |
| 2021-01-06 | @ | Wake Forest | W | 70-61 | |
| 2021-01-09 | vs. | Boston College | W | 49-61 | |
| 2021-01-13 | @ | Notre Dame | W | 80-68 | |
| 2021-01-16 | vs. | Clemson | W | 50-85 | |
| 2021-01-23 | @ | Georgia Tech | W | 64-62 | |
| 2021-01-25 | @ | Syracuse | W | 81-58 | |
| 2021-01-30 | vs. | Virginia Tech | L | 65-51 | |
| 2021-02-03 | vs. | North Carolina St. | W | 57-64 | |
| 2021-02-06 | @ | Pittsburgh | W | 73-66 | |
| 2021-02-10 | vs. | Georgia Tech | W | 49-57 | |
| 2021-02-13 | @ | North Carolina | W | 60-48 | |
| 2021-02-15 | vs. | Florida St. | L | 81-60 | |
| 2021-02-20 | vs. | Duke | L | 66-65 | |
| 2021-02-24 | @ | North Carolina St. | L | 61-68 | |
| 2021-03-01 | @ | Miami (FL) | W | 62-51 | |
| 2021-03-06 | vs. | Louisville | W | 58-68 | |
| 2021-03-11 | @ | Syracuse | W | 72-69 | |
| 2021-03-20 | @ | Ohio | L | 58-62 |