| 2020-11-25 | vs. | Utah St. | W | 69-85 | |
| 2020-11-26 | vs. | West Virginia | L | 78-66 | |
| 2020-11-27 | vs. | Memphis | W | 59-70 | |
| 2020-12-02 | vs. | Penn St. | L | 72-69 | |
| 2020-12-05 | @ | Mt. St. Mary's | W | 60-42 | |
| 2020-12-09 | @ | North Carolina A&T | W | 95-59 | |
| 2020-12-12 | @ | Old Dominion | W | 77-54 | |
| 2020-12-15 | @ | Western Caro. | W | 93-68 | |
| 2020-12-22 | @ | James Madison | W | 82-81 | |
| 2020-12-30 | vs. | Saint Joseph's | W | 64-80 | |
| 2021-01-06 | vs. | George Mason | W | 61-66 | |
| 2021-01-09 | @ | Rhode Island | L | 68-83 | |
| 2021-01-13 | vs. | George Washington | W | 77-84 | |
| 2021-01-20 | vs. | St. Bonaventure | L | 70-54 | |
| 2021-01-23 | @ | Dayton | W | 66-43 | |
| 2021-01-30 | @ | La Salle | W | 73-62 | |
| 2021-02-03 | vs. | Rhode Island | W | 62-63 | |
| 2021-02-09 | vs. | Dayton | W | 67-76 | |
| 2021-02-12 | @ | St. Bonaventure | W | 67-64 | |
| 2021-02-17 | @ | Richmond | W | 68-56 | |
| 2021-02-20 | @ | George Mason | L | 76-79 | OT |
| 2021-02-23 | @ | Saint Louis | W | 67-65 | |
| 2021-02-27 | vs. | Davidson | L | 65-57 | |
| 2021-03-05 | @ | Dayton | W | 73-68 | |
| 2021-03-06 | @ | Davidson | W | 64-52 | |
| 2021-03-14 | vs. | St. Bonaventure | L | 74-65 | |
| 2021-03-20 | vs. | Oregon | L | 1-0 |