| 2020-11-27 | vs. | Vanderbilt | L | 77-71 | |
| 2020-12-01 | vs. | Ill.-Chicago | L | 66-50 | |
| 2020-12-04 | vs. | Purdue | L | 68-61 | |
| 2020-12-09 | @ | SIUE | W | 80-58 | |
| 2020-12-12 | vs. | Central Mich. | L | 84-79 | |
| 2020-12-19 | vs. | Toledo | L | 71-57 | |
| 2021-01-09 | @ | Missouri St. | L | 68-81 | |
| 2021-01-10 | @ | Missouri St. | L | 68-78 | |
| 2021-01-16 | vs. | DePaul | L | 77-58 | |
| 2021-01-17 | vs. | Southern Ill. | |||
| 2021-01-20 | @ | Loyola Chicago | |||
| 2021-01-23 | vs. | Illinois St. | |||
| 2021-01-24 | vs. | Illinois St. | |||
| 2021-01-28 | @ | Bradley | |||
| 2021-01-31 | vs. | Evansville | |||
| 2021-02-01 | vs. | Evansville | |||
| 2021-02-06 | @ | Drake | |||
| 2021-02-07 | @ | Drake | |||
| 2021-02-12 | vs. | UNI |