| 2020-11-27 | vs. | Vanderbilt | L | 77-71 | |
| 2020-12-01 | vs. | Ill.-Chicago | L | 66-50 | |
| 2020-12-04 | vs. | Purdue | L | 68-61 | |
| 2020-12-09 | @ | SIUE | W | 80-58 | |
| 2020-12-12 | vs. | Central Mich. | L | 84-79 | |
| 2020-12-19 | vs. | Toledo | L | 71-57 | |
| 2021-01-09 | @ | Missouri St. | L | 68-81 | |
| 2021-01-10 | @ | Missouri St. | L | 68-78 | |
| 2021-01-16 | vs. | DePaul | L | 77-58 | |
| 2021-01-20 | @ | Loyola Chicago | L | 39-75 | |
| 2021-01-23 | vs. | Illinois St. | W | 60-69 | |
| 2021-01-24 | vs. | Illinois St. | W | 66-70 | |
| 2021-01-28 | @ | Bradley | W | 91-85 | 2OT |
| 2021-01-31 | vs. | Evansville | L | 70-52 | |
| 2021-02-01 | vs. | Evansville | L | 58-51 | |
| 2021-02-06 | @ | Drake | L | 77-80 | |
| 2021-02-07 | @ | Drake | W | 74-57 | |
| 2021-02-10 | @ | Bradley | L | 52-76 | |
| 2021-02-13 | vs. | UNI | W | 57-70 | |
| 2021-02-14 | vs. | UNI | L | 74-60 | |
| 2021-02-17 | vs. | Loyola Chicago | L | 54-52 | |
| 2021-02-21 | vs. | Southern Ill. | W | 65-66 | |
| 2021-02-22 | vs. | Southern Ill. | L | 67-64 | |
| 2021-02-26 | @ | Indiana St. | L | 43-58 | |
| 2021-02-27 | @ | Indiana St. | W | 70-58 | |
| 2021-03-05 | vs. | Missouri St. | L | 66-55 |