| 2020-12-02 | @ | Evansville | W | 93-87 | 2OT |
| 2020-12-18 | vs. | Southeast Mo. St. | W | 67-69 | |
| 2020-12-20 | @ | Western Ill. | L | 63-81 | |
| 2020-12-22 | vs. | Ole Miss | L | 90-43 | |
| 2020-12-30 | vs. | Jacksonville St. | L | 80-70 | |
| 2021-01-02 | @ | Belmont | L | 69-90 | |
| 2021-01-07 | vs. | Tennessee St. | L | 74-62 | |
| 2021-01-09 | vs. | Belmont | L | 89-69 | |
| 2021-01-16 | @ | Murray St. | L | 57-79 | |
| 2021-01-21 | vs. | Eastern Ky. | L | 113-73 | |
| 2021-01-23 | vs. | Morehead St. | L | 76-44 | |
| 2021-01-26 | @ | Southeast Mo. St. | W | 69-66 | |
| 2021-01-28 | @ | Eastern Ill. | W | 51-41 | |
| 2021-01-30 | @ | SIUE | L | 60-76 | |
| 2021-02-04 | @ | Jacksonville St. | L | 70-82 | |
| 2021-02-06 | @ | Tennessee Tech | W | 66-64 | |
| 2021-02-08 | @ | Austin Peay | W | 76-75 | |
| 2021-02-11 | vs. | Austin Peay | L | 71-50 | |
| 2021-02-13 | vs. | Murray St. | L | 84-55 | |
| 2021-02-18 | @ | Eastern Ky. | L | 72-89 | |
| 2021-02-20 | @ | Morehead St. | L | 69-79 | |
| 2021-02-25 | vs. | SIUE | L | 66-53 | |
| 2021-02-27 | vs. | Eastern Ill. | W | 68-73 |