| 2020-11-25 | @ | Central Conn. St. | W | 102-75 | |
| 2020-11-27 | @ | Hartford | W | 69-57 | |
| 2020-12-03 | @ | Southern California | W | 61-58 | |
| 2020-12-20 | @ | Creighton | L | 74-76 | OT |
| 2020-12-30 | @ | DePaul | W | 82-61 | |
| 2021-01-05 | vs. | Marquette | W | 54-65 | |
| 2021-01-09 | vs. | Butler | W | 60-72 | |
| 2021-01-11 | vs. | DePaul | W | 53-60 | |
| 2021-01-18 | @ | St. John's (NY) | L | 70-74 | |
| 2021-01-23 | vs. | Creighton | L | 74-66 | |
| 2021-01-26 | @ | Butler | W | 63-51 | |
| 2021-02-06 | @ | Seton Hall | L | 73-80 | |
| 2021-02-10 | vs. | Providence | L | 70-59 | |
| 2021-02-13 | vs. | Xavier | W | 72-80 | |
| 2021-02-16 | @ | Providence | W | 73-61 | |
| 2021-02-20 | vs. | Villanova | L | 68-60 | |
| 2021-02-23 | vs. | Georgetown | W | 57-70 | |
| 2021-02-27 | @ | Marquette | W | 80-62 | |
| 2021-03-03 | vs. | Seton Hall | W | 58-69 | |
| 2021-03-06 | @ | Georgetown | W | 98-82 | |
| 2021-03-11 | @ | DePaul | W | 94-60 | |
| 2021-03-12 | vs. | Creighton | L | 59-56 | |
| 2021-03-20 | @ | Maryland | L | 54-63 |