| 2020-11-30 | @ | Auburn | W | 63-55 | |
| 2020-12-06 | vs. | Michigan | L | 80-58 | |
| 2020-12-19 | vs. | Florida St. | W | 74-86 | |
| 2020-12-22 | @ | Cincinnati | W | 75-70 | |
| 2020-12-26 | @ | Houston | L | 54-63 | |
| 2021-01-02 | vs. | South Fla. | L | 68-61 | |
| 2021-01-14 | vs. | Temple | L | 62-55 | |
| 2021-01-17 | vs. | Houston | L | 75-58 | |
| 2021-01-23 | @ | SMU | L | 65-78 | |
| 2021-01-27 | @ | East Carolina | W | 71-64 | |
| 2021-01-30 | vs. | Wichita St. | L | 93-88 | OT |
| 2021-02-01 | vs. | Memphis | L | 96-69 | |
| 2021-02-03 | vs. | Memphis | L | 75-61 | |
| 2021-02-06 | vs. | Tulsa | W | 58-65 | |
| 2021-02-10 | @ | Wichita St. | L | 60-61 | |
| 2021-02-12 | @ | Tulane | W | 53-49 | |
| 2021-02-14 | vs. | Cincinnati | L | 69-68 | |
| 2021-02-17 | @ | South Fla. | W | 81-65 | |
| 2021-02-20 | vs. | Tulane | W | 81-84 | |
| 2021-03-02 | @ | Tulsa | W | 73-69 | |
| 2021-03-04 | vs. | East Carolina | W | 60-64 | |
| 2021-03-11 | @ | East Carolina | W | 72-62 | |
| 2021-03-12 | vs. | Memphis | L | 70-62 |