| 2020-11-25 | vs. | Bradley | L | 61-59 | |
| 2020-11-26 | vs. | Oakland | W | 53-80 | |
| 2020-11-27 | vs. | Xavier | L | 76-73 | |
| 2020-12-01 | @ | Cleveland St. | W | 70-61 | |
| 2020-12-04 | vs. | Eastern Mich. | W | 74-91 | |
| 2020-12-09 | vs. | Michigan | L | 91-71 | |
| 2020-12-12 | @ | UMKC | W | 64-57 | |
| 2020-12-16 | vs. | Marshall | W | 87-96 | OT |
| 2020-12-19 | @ | Valparaiso | W | 71-57 | |
| 2020-12-22 | @ | Northern Ill. | W | 78-55 | |
| 2021-01-02 | vs. | Western Mich. | W | 59-70 | |
| 2021-01-05 | vs. | Kent St. | W | 82-84 | |
| 2021-01-08 | @ | Ohio | W | 95-78 | |
| 2021-01-12 | @ | Eastern Mich. | W | 96-63 | |
| 2021-01-16 | vs. | Akron | L | 95-94 | OT |
| 2021-01-19 | @ | Central Mich. | W | 89-72 | |
| 2021-01-23 | @ | Kent St. | W | 76-74 | |
| 2021-01-26 | vs. | Miami (OH) | W | 81-90 | |
| 2021-01-30 | vs. | Bowling Green | W | 66-84 | |
| 2021-02-02 | @ | Akron | W | 91-76 | |
| 2021-02-06 | vs. | Ball St. | L | 81-67 | |
| 2021-02-13 | @ | Bowling Green | L | 81-88 | |
| 2021-02-16 | @ | Miami (OH) | W | 87-75 | |
| 2021-02-19 | vs. | Buffalo | W | 70-80 | |
| 2021-02-27 | @ | Western Mich. | W | 91-44 | |
| 2021-03-02 | vs. | Central Mich. | L | 81-79 | |
| 2021-03-05 | @ | Ball St. | W | 89-70 | |
| 2021-03-11 | @ | Ball St. | W | 91-89 | OT |
| 2021-03-12 | @ | Ohio | L | 80-87 | |
| 2021-03-17 | vs. | Richmond | L | 76-66 |