| 2020-11-25 | @ | Northwestern St. | W | 101-58 | |
| 2020-11-27 | @ | Sam Houston St. | W | 84-52 | |
| 2020-11-29 | vs. | Houston | L | 64-53 | |
| 2020-12-04 | @ | Troy | W | 80-46 | |
| 2020-12-06 | @ | Grambling | W | 81-40 | |
| 2020-12-09 | @ | Abilene Christian | W | 51-44 | |
| 2020-12-12 | @ | TX A&M-Corpus Christi | W | 77-57 | |
| 2020-12-17 | @ | Kansas | L | 57-58 | |
| 2020-12-22 | vs. | Oklahoma | W | 67-69 | |
| 2021-01-02 | @ | Oklahoma St. | L | 77-82 | OT |
| 2021-01-05 | @ | Kansas St. | W | 82-71 | |
| 2021-01-09 | vs. | Iowa St. | W | 64-91 | |
| 2021-01-13 | vs. | Texas | W | 77-79 | |
| 2021-01-16 | @ | Baylor | L | 60-68 | |
| 2021-01-20 | vs. | TCU | |||
| 2021-01-23 | @ | Iowa St. | |||
| 2021-01-25 | vs. | West Virginia | |||
| 2021-01-30 | vs. | LSU | |||
| 2021-02-01 | @ | Oklahoma | |||
| 2021-02-06 | vs. | Kansas St. | |||
| 2021-02-09 | @ | West Virginia | |||
| 2021-02-13 | vs. | Baylor |