| 2020-11-25 | @ | Northwestern St. | W | 101-58 | |
| 2020-11-27 | @ | Sam Houston St. | W | 84-52 | |
| 2020-11-29 | vs. | Houston | L | 64-53 | |
| 2020-12-04 | @ | Troy | W | 80-46 | |
| 2020-12-06 | @ | Grambling | W | 81-40 | |
| 2020-12-09 | @ | Abilene Christian | W | 51-44 | |
| 2020-12-12 | @ | TX A&M-Corpus Christi | W | 77-57 | |
| 2020-12-17 | @ | Kansas | L | 57-58 | |
| 2020-12-22 | vs. | Oklahoma | W | 67-69 | |
| 2021-01-02 | @ | Oklahoma St. | L | 77-82 | OT |
| 2021-01-05 | @ | Kansas St. | W | 82-71 | |
| 2021-01-09 | vs. | Iowa St. | W | 64-91 | |
| 2021-01-13 | vs. | Texas | W | 77-79 | |
| 2021-01-16 | @ | Baylor | L | 60-68 | |
| 2021-01-25 | vs. | West Virginia | L | 88-87 | |
| 2021-01-30 | vs. | LSU | W | 71-76 | |
| 2021-02-01 | @ | Oklahoma | W | 57-52 | |
| 2021-02-06 | vs. | Kansas St. | W | 62-73 | |
| 2021-02-09 | @ | West Virginia | L | 71-82 | |
| 2021-02-20 | vs. | Kansas | L | 67-61 | |
| 2021-02-22 | vs. | Oklahoma St. | L | 74-69 | OT |
| 2021-02-27 | @ | Texas | W | 68-59 | |
| 2021-03-02 | @ | TCU | W | 69-49 | |
| 2021-03-04 | @ | Iowa St. | W | 81-54 | |
| 2021-03-07 | vs. | Baylor | L | 88-73 | |
| 2021-03-11 | vs. | Texas | L | 67-66 | |
| 2021-03-19 | @ | Utah St. | W | 65-53 | |
| 2021-03-21 | vs. | Arkansas | L | 68-66 |