| 2020-11-25 | vs. | Indiana | L | 89-59 | |
| 2020-11-30 | @ | Chattanooga | L | 54-62 | |
| 2020-12-02 | vs. | Xavier | L | 79-48 | |
| 2020-12-03 | vs. | Northern Ky. | L | 74-65 | |
| 2020-12-06 | vs. | Western Caro. | L | 76-75 | OT |
| 2020-12-13 | @ | Jacksonville St. | L | 67-73 | |
| 2020-12-16 | vs. | Jacksonville St. | L | 74-50 | |
| 2020-12-18 | vs. | Tennessee | L | 103-49 | |
| 2020-12-22 | vs. | Western Ky. | L | 88-68 | |
| 2020-12-30 | @ | Southeast Mo. St. | W | 72-63 | |
| 2021-01-02 | vs. | Eastern Ill. | L | 87-81 | |
| 2021-01-07 | vs. | Morehead St. | L | 57-54 | |
| 2021-01-09 | vs. | Eastern Ky. | L | 90-80 | |
| 2021-01-14 | @ | Belmont | L | 67-88 | |
| 2021-01-16 | @ | Tennessee St. | W | 74-71 | |
| 2021-01-21 | vs. | Austin Peay | L | 72-69 | |
| 2021-01-23 | vs. | Murray St. | L | 72-63 | |
| 2021-01-30 | @ | Morehead St. | L | 55-74 | |
| 2021-02-04 | vs. | Southeast Mo. St. | L | 68-64 | |
| 2021-02-06 | vs. | UT Martin | L | 66-64 | |
| 2021-02-11 | @ | SIUE | L | 63-81 | |
| 2021-02-13 | @ | Eastern Ill. | W | 80-67 | |
| 2021-02-15 | @ | Eastern Ky. | L | 72-83 | |
| 2021-02-18 | vs. | Tennessee St. | L | 91-86 | |
| 2021-02-20 | vs. | Belmont | L | 90-66 | |
| 2021-02-25 | @ | Austin Peay | W | 81-76 | |
| 2021-02-27 | @ | Murray St. | W | 71-61 |