| 2020-12-08 | vs. | Belmont | L | 79-64 | |
| 2020-12-12 | vs. | IUPUI | L | 69-66 | |
| 2020-12-18 | @ | Belmont | L | 63-88 | |
| 2020-12-22 | @ | Chattanooga | L | 63-66 | |
| 2020-12-30 | @ | Austin Peay | L | 59-68 | |
| 2021-01-02 | vs. | Southeast Mo. St. | L | 83-79 | 2OT |
| 2021-01-07 | @ | UT Martin | W | 74-62 | |
| 2021-01-14 | vs. | Jacksonville St. | L | 65-64 | |
| 2021-01-16 | vs. | Tennessee Tech | L | 74-71 | |
| 2021-01-19 | @ | Southeast Mo. St. | L | 59-63 | |
| 2021-01-21 | @ | SIUE | L | 65-67 | |
| 2021-01-23 | @ | Eastern Ill. | W | 65-54 | |
| 2021-01-28 | vs. | Murray St. | L | 73-53 | |
| 2021-01-30 | vs. | Austin Peay | L | 71-56 | |
| 2021-02-04 | vs. | SIUE | L | 68-60 | |
| 2021-02-06 | vs. | Eastern Ill. | L | 86-72 | |
| 2021-02-11 | @ | Morehead St. | L | 66-79 | |
| 2021-02-13 | @ | Eastern Ky. | L | 73-93 | |
| 2021-02-18 | @ | Tennessee Tech | W | 91-86 | |
| 2021-02-20 | @ | Jacksonville St. | L | 76-77 | |
| 2021-02-25 | vs. | Morehead St. | L | 74-60 | |
| 2021-02-27 | vs. | Eastern Ky. | L | 89-84 |