| 2020-11-25 | @ | Houston Baptist | W | 69-45 | |
| 2020-11-28 | @ | Tulsa | W | 70-65 | |
| 2020-11-29 | vs. | Liberty | W | 52-56 | |
| 2020-12-03 | @ | Northwestern St. | W | 74-68 | |
| 2020-12-06 | @ | Oklahoma | L | 78-82 | |
| 2020-12-09 | @ | Providence | L | 70-79 | |
| 2020-12-12 | @ | Texas A&M | W | 73-55 | |
| 2020-12-16 | vs. | Oklahoma St. | W | 76-77 | |
| 2020-12-22 | @ | North Dakota St. | W | 89-82 | |
| 2020-12-30 | @ | Prairie View | W | 66-61 | |
| 2021-01-02 | vs. | Kansas St. | W | 60-67 | |
| 2021-01-05 | @ | Kansas | L | 64-93 | |
| 2021-01-09 | @ | Baylor | L | 49-67 | |
| 2021-01-12 | vs. | Oklahoma | L | 82-46 | |
| 2021-01-28 | vs. | Kansas | L | 59-51 | |
| 2021-01-30 | vs. | Missouri | L | 102-98 | OT |
| 2021-02-03 | @ | Oklahoma St. | W | 81-78 | |
| 2021-02-09 | @ | Iowa St. | W | 79-76 | |
| 2021-02-13 | vs. | Texas | L | 70-55 | |
| 2021-02-20 | @ | Kansas St. | L | 54-62 | |
| 2021-02-23 | @ | West Virginia | L | 66-74 | |
| 2021-02-27 | vs. | Iowa St. | W | 72-76 | |
| 2021-03-02 | vs. | Texas Tech | L | 69-49 | |
| 2021-03-04 | vs. | West Virginia | L | 76-67 | |
| 2021-03-07 | @ | Texas | L | 64-76 | |
| 2021-03-10 | @ | Kansas St. | L | 50-71 |