| 2020-11-25 | @ | Houston Baptist | W | 69-45 | |
| 2020-11-28 | @ | Tulsa | W | 70-65 | |
| 2020-11-29 | vs. | Liberty | W | 52-56 | |
| 2020-12-03 | @ | Northwestern St. | W | 74-68 | |
| 2020-12-06 | @ | Oklahoma | L | 78-82 | |
| 2020-12-09 | @ | Providence | L | 70-79 | |
| 2020-12-12 | @ | Texas A&M | W | 73-55 | |
| 2020-12-16 | vs. | Oklahoma St. | W | 76-77 | |
| 2020-12-22 | @ | North Dakota St. | W | 89-82 | |
| 2020-12-30 | @ | Prairie View | W | 66-61 | |
| 2021-01-02 | vs. | Kansas St. | W | 60-67 | |
| 2021-01-05 | @ | Kansas | L | 64-93 | |
| 2021-01-09 | @ | Baylor | L | 49-67 | |
| 2021-01-12 | vs. | Oklahoma | L | 82-46 | |
| 2021-01-16 | vs. | West Virginia | |||
| 2021-01-20 | @ | Texas Tech | |||
| 2021-01-23 | @ | Texas | |||
| 2021-01-26 | vs. | Kansas | |||
| 2021-01-30 | vs. | Missouri | |||
| 2021-02-03 | @ | Oklahoma St. | |||
| 2021-02-06 | vs. | Baylor | |||
| 2021-02-09 | @ | Iowa St. |