| 2020-11-27 | @ | Bryant | W | 85-84 | |
| 2020-12-03 | @ | Niagara | W | 75-45 | |
| 2020-12-05 | @ | Rider | W | 87-52 | |
| 2020-12-08 | vs. | Rutgers | L | 79-69 | |
| 2020-12-12 | vs. | Boston College | W | 63-101 | |
| 2020-12-16 | @ | Northeastern | W | 62-56 | |
| 2020-12-19 | @ | Buffalo | W | 107-96 | OT |
| 2021-01-06 | @ | Pittsburgh | L | 60-63 | |
| 2021-01-09 | @ | Georgetown | W | 74-69 | |
| 2021-01-12 | vs. | North Carolina | L | 81-75 | |
| 2021-01-16 | vs. | Pittsburgh | L | 96-76 | |
| 2021-01-19 | @ | Miami (FL) | W | 83-57 | |
| 2021-01-23 | @ | Virginia Tech | W | 78-60 | |
| 2021-01-25 | vs. | Virginia | L | 81-58 | |
| 2021-01-31 | @ | North Carolina St. | W | 76-73 | |
| 2021-02-06 | vs. | Clemson | L | 78-61 | |
| 2021-02-09 | vs. | North Carolina St. | W | 68-77 | |
| 2021-02-13 | @ | Boston College | W | 75-67 | |
| 2021-02-20 | @ | Notre Dame | W | 75-67 | |
| 2021-02-22 | vs. | Duke | L | 85-71 | |
| 2021-02-27 | vs. | Georgia Tech | L | 84-77 | |
| 2021-03-01 | @ | North Carolina | W | 72-70 | |
| 2021-03-03 | @ | Clemson | W | 64-54 | |
| 2021-03-10 | @ | North Carolina St. | W | 89-68 | |
| 2021-03-11 | vs. | Virginia | L | 72-69 | |
| 2021-03-19 | vs. | San Diego St. | W | 62-78 | |
| 2021-03-21 | vs. | West Virginia | W | 72-75 | |
| 2021-03-27 | vs. | Houston | L | 62-46 |