| 2020-11-28 | vs. | Jacksonville | L | 66-51 | |
| 2020-12-09 | vs. | Tulane | L | 58-38 | |
| 2020-12-12 | @ | South Ala. | L | 75-76 | |
| 2020-12-15 | vs. | Lamar University | W | 63-66 | |
| 2020-12-19 | @ | La.-Monroe | W | 60-47 | |
| 2021-01-01 | @ | UTEP | W | 74-66 | OT |
| 2021-01-02 | @ | UTEP | L | 62-77 | |
| 2021-01-08 | vs. | UAB | L | 72-60 | |
| 2021-01-09 | vs. | UAB | L | 62-58 | |
| 2021-01-15 | @ | Middle Tenn. | W | 84-54 | |
| 2021-01-16 | @ | Middle Tenn. | W | 64-59 | |
| 2021-01-22 | vs. | UTSA | L | 70-64 | |
| 2021-01-23 | vs. | UTSA | L | 78-72 | |
| 2021-01-28 | @ | Louisiana Tech | L | 63-76 | |
| 2021-01-30 | vs. | Louisiana Tech | L | 65-62 | |
| 2021-02-05 | vs. | Rice | L | 88-62 | |
| 2021-02-06 | vs. | Rice | L | 76-68 | |
| 2021-02-12 | @ | North Texas | L | 49-65 | |
| 2021-02-13 | @ | North Texas | L | 56-68 | |
| 2021-02-19 | vs. | FIU | W | 72-85 | |
| 2021-02-26 | @ | Fla. Atlantic | L | 60-69 | |
| 2021-02-27 | @ | Fla. Atlantic | L | 66-73 | |
| 2021-03-09 | vs. | Rice | L | 61-52 |