| 2020-12-02 | vs. | Southeast Mo. St. | W | 79-87 | OT |
| 2020-12-11 | @ | Murray St. | W | 70-66 | |
| 2020-12-17 | @ | North Dakota | W | 85-64 | |
| 2020-12-18 | @ | North Dakota | W | 62-50 | |
| 2020-12-21 | vs. | Butler | W | 73-76 | |
| 2020-12-27 | @ | Evansville | W | 63-57 | |
| 2020-12-28 | @ | Evansville | L | 72-84 | |
| 2021-01-03 | vs. | Drake | L | 73-55 | |
| 2021-01-04 | vs. | Drake | L | 86-55 | |
| 2021-01-25 | vs. | Indiana St. | L | 69-66 | |
| 2021-01-26 | vs. | Indiana St. | L | 71-59 | |
| 2021-01-30 | @ | UNI | L | 62-74 | |
| 2021-01-31 | @ | UNI | W | 71-68 | |
| 2021-02-06 | vs. | Bradley | L | 74-66 | |
| 2021-02-07 | vs. | Bradley | W | 68-69 | |
| 2021-02-10 | vs. | Missouri St. | L | 65-53 | |
| 2021-02-13 | @ | Illinois St. | L | 55-80 | |
| 2021-02-14 | @ | Illinois St. | W | 59-49 | |
| 2021-02-17 | @ | Missouri St. | L | 53-68 | |
| 2021-02-21 | @ | Valparaiso | L | 65-66 | |
| 2021-02-22 | @ | Valparaiso | W | 67-64 | |
| 2021-02-26 | vs. | Loyola Chicago | L | 60-52 | |
| 2021-02-27 | vs. | Loyola Chicago | L | 65-58 | OT |
| 2021-03-04 | vs. | Bradley | W | 63-73 | |
| 2021-03-05 | vs. | Loyola Chicago | L | 73-49 |