| 2020-11-28 | vs. | UMKC | W | 66-71 | |
| 2020-12-02 | @ | Southern Ill. | L | 79-87 | OT |
| 2020-12-07 | @ | Lipscomb | W | 82-77 | |
| 2020-12-09 | vs. | Lipscomb | L | 80-74 | OT |
| 2020-12-15 | vs. | Evansville | L | 66-63 | OT |
| 2020-12-18 | @ | UT Martin | L | 67-69 | |
| 2020-12-22 | vs. | Indiana St. | L | 72-66 | |
| 2020-12-30 | vs. | Tennessee Tech | L | 72-63 | |
| 2021-01-02 | @ | Tennessee St. | W | 83-79 | 2OT |
| 2021-01-07 | vs. | Belmont | L | 77-66 | |
| 2021-01-16 | @ | Morehead St. | L | 50-64 | |
| 2021-01-19 | vs. | Tennessee St. | W | 59-63 | |
| 2021-01-21 | vs. | Morehead St. | L | 76-65 | |
| 2021-01-26 | vs. | UT Martin | L | 69-66 | |
| 2021-01-28 | @ | SIUE | W | 64-62 | |
| 2021-01-30 | @ | Eastern Ill. | W | 75-44 | |
| 2021-02-01 | @ | Murray St. | L | 60-77 | |
| 2021-02-04 | @ | Tennessee Tech | W | 68-64 | |
| 2021-02-06 | @ | Jacksonville St. | L | 54-66 | |
| 2021-02-12 | vs. | Murray St. | L | 80-60 | |
| 2021-02-13 | vs. | Austin Peay | L | 78-63 | |
| 2021-02-16 | @ | Austin Peay | W | 86-81 | OT |
| 2021-02-20 | @ | Eastern Ky. | W | 94-72 | |
| 2021-02-22 | @ | Eastern Ky. | L | 65-87 | |
| 2021-02-25 | vs. | Eastern Ill. | W | 88-94 | |
| 2021-02-27 | vs. | SIUE | W | 63-69 | |
| 2021-03-03 | vs. | Morehead St. | L | 61-54 |