| 2020-11-27 | vs. | Louisville | L | 71-70 | |
| 2020-11-30 | @ | Iona | W | 86-64 | |
| 2020-12-02 | vs. | Rhode Island | L | 76-63 | |
| 2020-12-04 | vs. | Oregon | L | 83-70 | |
| 2020-12-06 | vs. | Penn St. | W | 92-98 | OT |
| 2020-12-08 | @ | Wagner | W | 78-45 | |
| 2020-12-11 | @ | St. John's (NY) | W | 77-68 | |
| 2020-12-17 | vs. | Marquette | W | 63-70 | |
| 2020-12-20 | @ | Providence | L | 77-80 | OT |
| 2020-12-23 | @ | Georgetown | W | 78-67 | |
| 2020-12-30 | vs. | Xavier | W | 68-85 | |
| 2021-01-02 | @ | Butler | W | 68-60 | |
| 2021-01-06 | vs. | Creighton | L | 89-53 | |
| 2021-01-09 | vs. | DePaul | W | 68-76 | |
| 2021-01-19 | vs. | Villanova | L | 76-74 | |
| 2021-01-27 | @ | Creighton | L | 81-85 | |
| 2021-01-30 | @ | Villanova | L | 72-80 | |
| 2021-02-03 | vs. | Providence | W | 43-60 | |
| 2021-02-06 | vs. | UConn | W | 73-80 | |
| 2021-02-14 | @ | Marquette | W | 57-51 | |
| 2021-02-17 | @ | DePaul | W | 60-52 | |
| 2021-02-20 | vs. | Georgetown | L | 81-75 | |
| 2021-02-24 | vs. | Butler | L | 61-52 | |
| 2021-03-03 | @ | UConn | L | 58-69 | |
| 2021-03-06 | vs. | St. John's (NY) | L | 81-71 | |
| 2021-03-11 | vs. | St. John's (NY) | W | 69-77 | OT |
| 2021-03-12 | @ | Georgetown | L | 58-66 |