| 2020-11-25 | vs. | SMU | L | 97-67 | |
| 2020-11-27 | vs. | Texas Tech | L | 84-52 | |
| 2020-11-29 | @ | Boise St. | L | 55-86 | |
| 2020-12-14 | vs. | LSU | L | 88-66 | |
| 2020-12-16 | vs. | Texas | L | 79-63 | |
| 2020-12-19 | @ | Rice | W | 82-69 | |
| 2020-12-21 | vs. | UTRGV | W | 66-69 | |
| 2021-01-02 | vs. | Nicholls St. | W | 81-84 | |
| 2021-01-06 | vs. | Southeastern La. | W | 52-70 | |
| 2021-01-09 | vs. | Central Ark. | W | 80-91 | |
| 2021-01-13 | @ | Lamar University | W | 96-71 | |
| 2021-01-16 | @ | Houston Baptist | W | 87-80 | |
| 2021-01-20 | @ | Abilene Christian | W | 64-57 | |
| 2021-01-27 | vs. | TX A&M-Corpus Christi | W | 70-75 | |
| 2021-01-31 | vs. | SFA | L | 78-68 | |
| 2021-02-06 | @ | Nicholls St. | W | 78-71 | |
| 2021-02-10 | @ | Southeastern La. | W | 79-61 | |
| 2021-02-13 | @ | Central Ark. | W | 97-57 | |
| 2021-02-22 | vs. | Lamar University | W | 71-77 | |
| 2021-02-24 | vs. | Abilene Christian | L | 86-72 | |
| 2021-03-01 | vs. | Houston Baptist | W | 70-83 | |
| 2021-03-03 | @ | TX A&M-Corpus Christi | W | 84-61 | |
| 2021-03-06 | @ | SFA | L | 59-64 | |
| 2021-03-11 | @ | Lamar University | L | 69-70 |