| 2020-11-26 | vs. | Auburn | L | 96-91 | OT |
| 2020-11-27 | vs. | Kansas | L | 94-72 | |
| 2020-12-17 | vs. | Drexel | L | 81-77 | |
| 2020-12-19 | vs. | Villanova | L | 88-68 | |
| 2020-12-21 | vs. | Tennessee | L | 102-66 | |
| 2020-12-30 | @ | VCU | L | 64-80 | |
| 2021-01-03 | vs. | Rhode Island | L | 85-77 | OT |
| 2021-01-06 | vs. | St. Bonaventure | L | 83-57 | |
| 2021-01-09 | @ | Albany (NY) | W | 67-64 | |
| 2021-01-12 | vs. | Davidson | L | 80-66 | |
| 2021-01-18 | vs. | La Salle | L | 90-83 | |
| 2021-01-20 | vs. | George Mason | L | 87-85 | 2OT |
| 2021-01-23 | @ | George Mason | L | 62-71 | |
| 2021-01-26 | @ | Richmond | L | 56-79 | |
| 2021-01-30 | vs. | Duquesne | L | 67-50 | |
| 2021-02-20 | @ | La Salle | W | 91-82 | OT |
| 2021-02-24 | @ | Dayton | W | 97-84 | |
| 2021-03-01 | vs. | Richmond | W | 73-76 | |
| 2021-03-03 | vs. | La Salle | W | 66-72 | |
| 2021-03-04 | vs. | Massachusetts | L | 100-66 |