| 2020-11-25 | @ | Sacred Heart | W | 86-63 | |
| 2020-11-27 | @ | Fairleigh Dickinson | W | 96-75 | |
| 2020-11-29 | @ | Hofstra | W | 70-56 | |
| 2020-12-08 | @ | Syracuse | W | 79-69 | |
| 2020-12-14 | vs. | Maryland | W | 60-74 | |
| 2020-12-20 | @ | Illinois | W | 91-88 | |
| 2020-12-23 | vs. | Ohio St. | L | 80-68 | |
| 2020-12-29 | @ | Purdue | W | 81-76 | |
| 2021-01-02 | @ | Iowa | L | 75-77 | |
| 2021-01-05 | vs. | Michigan St. | L | 68-45 | |
| 2021-01-09 | @ | Ohio St. | L | 68-79 | |
| 2021-01-12 | vs. | Penn St. | |||
| 2021-01-15 | @ | Wisconsin | |||
| 2021-01-21 | vs. | Penn St. | |||
| 2021-01-24 | vs. | Indiana | |||
| 2021-01-28 | @ | Michigan St. | |||
| 2021-01-31 | vs. | Northwestern | |||
| 2021-02-04 | @ | Minnesota | |||
| 2021-02-10 | vs. | Iowa |