| 2020-11-25 | @ | Sacred Heart | W | 86-63 | |
| 2020-11-27 | @ | Fairleigh Dickinson | W | 96-75 | |
| 2020-11-29 | @ | Hofstra | W | 70-56 | |
| 2020-12-08 | @ | Syracuse | W | 79-69 | |
| 2020-12-14 | vs. | Maryland | W | 60-74 | |
| 2020-12-20 | @ | Illinois | W | 91-88 | |
| 2020-12-23 | vs. | Ohio St. | L | 80-68 | |
| 2020-12-29 | @ | Purdue | W | 81-76 | |
| 2021-01-02 | @ | Iowa | L | 75-77 | |
| 2021-01-05 | vs. | Michigan St. | L | 68-45 | |
| 2021-01-09 | @ | Ohio St. | L | 68-79 | |
| 2021-01-15 | @ | Wisconsin | L | 54-60 | |
| 2021-01-21 | vs. | Penn St. | L | 75-67 | |
| 2021-01-24 | vs. | Indiana | W | 70-74 | |
| 2021-01-28 | @ | Michigan St. | W | 67-37 | |
| 2021-01-31 | vs. | Northwestern | W | 56-64 | |
| 2021-02-04 | @ | Minnesota | W | 76-72 | |
| 2021-02-10 | vs. | Iowa | L | 79-66 | |
| 2021-02-13 | @ | Northwestern | W | 64-50 | |
| 2021-02-18 | vs. | Michigan | L | 71-64 | |
| 2021-02-21 | @ | Maryland | L | 59-68 | |
| 2021-02-24 | @ | Indiana | W | 74-63 | |
| 2021-03-01 | vs. | Nebraska | L | 72-51 | |
| 2021-03-06 | vs. | Minnesota | W | 70-77 | OT |
| 2021-03-11 | @ | Indiana | W | 61-50 | |
| 2021-03-12 | vs. | Illinois | L | 90-68 | |
| 2021-03-19 | vs. | Clemson | W | 56-60 | |
| 2021-03-21 | vs. | Houston | L | 63-60 |