| 2020-11-25 | vs. | Arizona St. | L | 94-88 | |
| 2020-11-26 | @ | Boston College | L | 64-69 | |
| 2020-11-28 | vs. | South Fla. | W | 68-84 | |
| 2020-11-29 | @ | San Francisco | W | 84-71 | |
| 2020-12-02 | @ | Seton Hall | W | 76-63 | |
| 2020-12-09 | vs. | Wisconsin | L | 73-62 | |
| 2020-12-13 | vs. | Western Ky. | L | 68-65 | |
| 2020-12-18 | @ | Davidson | L | 58-67 | |
| 2020-12-30 | @ | St. Bonaventure | W | 63-57 | |
| 2021-01-03 | @ | Saint Joseph's | W | 85-77 | OT |
| 2021-01-06 | vs. | Richmond | L | 80-73 | |
| 2021-01-09 | vs. | VCU | W | 68-83 | |
| 2021-01-13 | vs. | Massachusetts | L | 80-78 | OT |
| 2021-01-16 | @ | George Mason | W | 80-60 | |
| 2021-01-20 | vs. | Duquesne | L | 71-69 | |
| 2021-01-24 | @ | Fordham | W | 52-42 | |
| 2021-01-27 | vs. | La Salle | W | 60-73 | |
| 2021-01-30 | vs. | Dayton | L | 67-56 | |
| 2021-02-03 | @ | VCU | L | 62-63 | |
| 2021-02-06 | @ | Massachusetts | L | 63-75 | |
| 2021-02-10 | vs. | Saint Louis | L | 67-60 | |
| 2021-02-16 | @ | Dayton | W | 91-89 | 2OT |
| 2021-02-21 | vs. | George Washington | L | 78-70 | |
| 2021-02-27 | vs. | Duquesne | L | 86-75 | |
| 2021-03-04 | vs. | Dayton | L | 84-72 |