| 2020-11-25 | @ | Liberty | W | 77-64 | |
| 2020-11-26 | vs. | Clemson | L | 81-70 | |
| 2020-12-01 | @ | Oakland | W | 93-50 | |
| 2020-12-04 | @ | Valparaiso | W | 68-61 | |
| 2020-12-08 | vs. | Miami (FL) | L | 58-54 | |
| 2020-12-12 | @ | Indiana St. | W | 80-68 | |
| 2020-12-16 | @ | Ohio St. | W | 67-60 | |
| 2020-12-19 | vs. | Notre Dame | W | 78-88 | |
| 2020-12-22 | vs. | Iowa | L | 70-55 | |
| 2020-12-25 | @ | Maryland | W | 73-70 | |
| 2020-12-29 | vs. | Rutgers | L | 81-76 | |
| 2021-01-02 | vs. | Illinois | L | 66-58 | |
| 2021-01-08 | vs. | Michigan St. | W | 54-55 | |
| 2021-01-14 | vs. | Indiana | W | 69-81 | |
| 2021-01-17 | @ | Penn St. | W | 80-72 | |
| 2021-01-19 | vs. | Ohio St. | W | 65-67 | |
| 2021-01-22 | @ | Michigan | L | 53-70 | |
| 2021-01-30 | @ | Minnesota | W | 81-62 | |
| 2021-02-02 | vs. | Maryland | L | 61-60 | |
| 2021-02-06 | @ | Northwestern | W | 75-70 | |
| 2021-02-11 | vs. | Minnesota | L | 71-68 | |
| 2021-02-16 | @ | Michigan St. | W | 75-65 | |
| 2021-02-20 | vs. | Nebraska | W | 58-75 | |
| 2021-02-26 | vs. | Penn St. | W | 52-73 | |
| 2021-03-02 | @ | Wisconsin | W | 73-69 | |
| 2021-03-06 | @ | Indiana | W | 67-58 | |
| 2021-03-12 | @ | Ohio St. | L | 78-87 | OT |
| 2021-03-19 | @ | North Texas | L | 69-78 | OT |