| 2020-11-25 | @ | Fairfield | W | 97-56 | |
| 2020-11-30 | @ | Indiana | L | 58-79 | |
| 2020-12-01 | @ | Davidson | W | 63-62 | |
| 2020-12-02 | vs. | Alabama | L | 88-71 | |
| 2020-12-05 | @ | Fairleigh Dickinson | W | 79-67 | |
| 2020-12-09 | vs. | TCU | W | 70-79 | |
| 2020-12-20 | vs. | Seton Hall | W | 77-80 | OT |
| 2020-12-23 | vs. | Butler | L | 70-64 | |
| 2020-12-27 | @ | DePaul | W | 95-90 | 2OT |
| 2020-12-30 | @ | Butler | W | 71-55 | |
| 2021-01-02 | @ | Creighton | L | 65-67 | |
| 2021-01-10 | vs. | Xavier | L | 74-73 | |
| 2021-01-12 | vs. | Marquette | L | 79-69 | |
| 2021-01-20 | vs. | Creighton | W | 70-74 | |
| 2021-01-23 | vs. | Villanova | L | 71-56 | |
| 2021-01-27 | @ | Marquette | W | 72-63 | OT |
| 2021-01-30 | vs. | Georgetown | L | 73-72 | |
| 2021-02-03 | @ | Seton Hall | L | 43-60 | |
| 2021-02-06 | @ | St. John's (NY) | L | 81-92 | |
| 2021-02-10 | @ | UConn | W | 70-59 | |
| 2021-02-13 | vs. | DePaul | W | 47-57 | |
| 2021-02-16 | vs. | UConn | L | 73-61 | |
| 2021-02-24 | @ | Xavier | W | 83-68 | |
| 2021-03-03 | vs. | St. John's (NY) | L | 81-67 | |
| 2021-03-06 | @ | Villanova | W | 54-52 | |
| 2021-03-10 | @ | DePaul | L | 62-70 |