| 2020-11-25 | @ | Saint Francis (PA) | L | 70-80 | |
| 2020-11-28 | @ | Drexel | W | 83-74 | |
| 2020-12-05 | @ | Northern Ill. | W | 89-59 | |
| 2020-12-09 | vs. | Northwestern | W | 70-71 | |
| 2020-12-12 | @ | Gardner-Webb | W | 67-50 | |
| 2020-12-16 | vs. | Miami (FL) | W | 55-70 | |
| 2020-12-22 | @ | Louisville | L | 54-64 | |
| 2021-01-06 | vs. | Syracuse | W | 60-63 | |
| 2021-01-16 | @ | Syracuse | W | 96-76 | |
| 2021-01-19 | @ | Duke | W | 79-73 | |
| 2021-01-23 | vs. | Wake Forest | L | 76-75 | |
| 2021-01-26 | @ | North Carolina | L | 65-75 | |
| 2021-01-30 | @ | Notre Dame | L | 58-84 | |
| 2021-02-03 | @ | Virginia Tech | W | 83-72 | |
| 2021-02-06 | vs. | Virginia | L | 73-66 | |
| 2021-02-14 | vs. | Georgia Tech | L | 71-65 | |
| 2021-02-17 | @ | North Carolina St. | L | 73-74 | |
| 2021-02-20 | @ | Florida St. | L | 72-79 | |
| 2021-02-28 | vs. | North Carolina St. | L | 65-62 | |
| 2021-03-02 | @ | Wake Forest | W | 70-57 | |
| 2021-03-06 | vs. | Clemson | L | 77-62 | |
| 2021-03-09 | @ | Miami (FL) | L | 73-79 |