| 2020-11-25 | vs. | UT Arlington | W | 68-75 | |
| 2020-11-28 | @ | Texas Southern | W | 85-65 | |
| 2020-12-01 | vs. | Marquette | W | 62-70 | |
| 2020-12-05 | @ | Oakland | W | 84-71 | |
| 2020-12-08 | @ | Oral Roberts | W | 83-78 | |
| 2020-12-12 | vs. | Wichita St. | W | 64-67 | |
| 2020-12-16 | @ | TCU | L | 76-77 | |
| 2020-12-20 | vs. | Texas | L | 77-74 | |
| 2021-01-02 | vs. | Texas Tech | W | 77-82 | OT |
| 2021-01-04 | @ | West Virginia | L | 84-87 | |
| 2021-01-09 | vs. | Kansas St. | W | 54-70 | |
| 2021-01-12 | @ | Kansas | W | 75-70 | |
| 2021-01-23 | @ | Baylor | L | 66-81 | |
| 2021-01-25 | vs. | Iowa St. | W | 60-81 | |
| 2021-01-30 | @ | Arkansas | W | 81-77 | |
| 2021-02-03 | vs. | TCU | L | 81-78 | |
| 2021-02-06 | @ | Texas | W | 75-67 | 2OT |
| 2021-02-08 | vs. | Kansas | L | 78-66 | |
| 2021-02-13 | @ | Kansas St. | W | 67-60 | |
| 2021-02-16 | @ | Iowa St. | W | 76-58 | |
| 2021-02-22 | @ | Texas Tech | W | 74-69 | OT |
| 2021-02-27 | vs. | Oklahoma | W | 90-94 | OT |
| 2021-03-01 | @ | Oklahoma | W | 79-75 | |
| 2021-03-04 | vs. | Baylor | L | 81-70 | |
| 2021-03-06 | vs. | West Virginia | W | 80-85 | |
| 2021-03-11 | vs. | West Virginia | W | 69-72 | |
| 2021-03-12 | vs. | Baylor | W | 74-83 | |
| 2021-03-19 | @ | Liberty | W | 69-60 | |
| 2021-03-21 | @ | Oregon St. | L | 70-80 |