| 2020-12-03 | @ | UTSA | W | 105-66 | |
| 2020-12-06 | vs. | TCU | W | 78-82 | |
| 2020-12-09 | vs. | Xavier | L | 99-77 | |
| 2020-12-12 | @ | Florida A&M | W | 85-54 | |
| 2020-12-16 | @ | Oral Roberts | W | 79-65 | |
| 2020-12-19 | @ | Houston Baptist | W | 84-65 | |
| 2020-12-22 | @ | Texas Tech | L | 67-69 | |
| 2021-01-02 | @ | West Virginia | W | 75-71 | |
| 2021-01-06 | vs. | Baylor | L | 76-61 | |
| 2021-01-09 | vs. | Kansas | L | 63-59 | |
| 2021-01-12 | @ | TCU | W | 82-46 | |
| 2021-01-19 | @ | Kansas St. | W | 76-50 | |
| 2021-01-23 | @ | Kansas | W | 75-68 | |
| 2021-01-26 | vs. | Texas | |||
| 2021-01-30 | @ | Alabama | |||
| 2021-02-01 | vs. | Texas Tech | |||
| 2021-02-06 | @ | Iowa St. | |||
| 2021-02-10 | @ | Baylor | |||
| 2021-02-13 | vs. | West Virginia |