| 2020-12-03 | @ | UTSA | W | 105-66 | |
| 2020-12-06 | vs. | TCU | W | 78-82 | |
| 2020-12-09 | vs. | Xavier | L | 99-77 | |
| 2020-12-12 | @ | Florida A&M | W | 85-54 | |
| 2020-12-16 | @ | Oral Roberts | W | 79-65 | |
| 2020-12-19 | @ | Houston Baptist | W | 84-65 | |
| 2020-12-22 | @ | Texas Tech | L | 67-69 | |
| 2021-01-02 | @ | West Virginia | W | 75-71 | |
| 2021-01-06 | vs. | Baylor | L | 76-61 | |
| 2021-01-09 | vs. | Kansas | L | 63-59 | |
| 2021-01-12 | @ | TCU | W | 82-46 | |
| 2021-01-19 | @ | Kansas St. | W | 76-50 | |
| 2021-01-23 | @ | Kansas | W | 75-68 | |
| 2021-01-26 | vs. | Texas | W | 79-80 | |
| 2021-01-30 | @ | Alabama | W | 66-61 | |
| 2021-02-01 | vs. | Texas Tech | L | 57-52 | |
| 2021-02-06 | @ | Iowa St. | W | 79-72 | |
| 2021-02-13 | vs. | West Virginia | W | 90-91 | 2OT |
| 2021-02-20 | vs. | Iowa St. | W | 56-66 | |
| 2021-02-23 | vs. | Kansas St. | L | 62-57 | |
| 2021-02-27 | @ | Oklahoma St. | L | 90-94 | OT |
| 2021-03-01 | vs. | Oklahoma St. | L | 79-75 | |
| 2021-03-04 | @ | Texas | L | 65-69 | |
| 2021-03-10 | @ | Iowa St. | W | 79-73 | |
| 2021-03-11 | vs. | Kansas | L | 69-62 | |
| 2021-03-20 | @ | Missouri | W | 72-68 | |
| 2021-03-22 | vs. | Gonzaga | L | 87-71 |