| 2020-11-25 | @ | Illinois St. | W | 94-67 | |
| 2020-11-29 | @ | UMass Lowell | W | 74-64 | |
| 2020-12-02 | @ | Morehead St. | W | 77-44 | |
| 2020-12-08 | vs. | Notre Dame | W | 85-90 | |
| 2020-12-13 | @ | Cleveland St. | W | 67-61 | |
| 2020-12-16 | vs. | Purdue | L | 67-60 | |
| 2020-12-19 | @ | UCLA | W | 77-70 | |
| 2020-12-23 | @ | Rutgers | W | 80-68 | |
| 2020-12-26 | vs. | Northwestern | L | 71-70 | |
| 2020-12-30 | @ | Nebraska | W | 90-54 | |
| 2021-01-03 | vs. | Minnesota | L | 77-60 | |
| 2021-01-09 | vs. | Rutgers | W | 68-79 | |
| 2021-01-13 | @ | Northwestern | W | 81-71 | |
| 2021-01-16 | vs. | Illinois | W | 81-87 | |
| 2021-01-19 | @ | Purdue | L | 65-67 | |
| 2021-01-23 | vs. | Wisconsin | |||
| 2021-01-31 | @ | Michigan St. | |||
| 2021-02-04 | vs. | Iowa | |||
| 2021-02-08 | vs. | Maryland |