| 2020-11-25 | @ | Illinois St. | W | 94-67 | |
| 2020-11-29 | @ | UMass Lowell | W | 74-64 | |
| 2020-12-02 | @ | Morehead St. | W | 77-44 | |
| 2020-12-08 | vs. | Notre Dame | W | 85-90 | |
| 2020-12-13 | @ | Cleveland St. | W | 67-61 | |
| 2020-12-16 | vs. | Purdue | L | 67-60 | |
| 2020-12-19 | @ | UCLA | W | 77-70 | |
| 2020-12-23 | @ | Rutgers | W | 80-68 | |
| 2020-12-26 | vs. | Northwestern | L | 71-70 | |
| 2020-12-30 | @ | Nebraska | W | 90-54 | |
| 2021-01-03 | vs. | Minnesota | L | 77-60 | |
| 2021-01-09 | vs. | Rutgers | W | 68-79 | |
| 2021-01-13 | @ | Northwestern | W | 81-71 | |
| 2021-01-16 | vs. | Illinois | W | 81-87 | |
| 2021-01-19 | @ | Purdue | L | 65-67 | |
| 2021-01-23 | vs. | Wisconsin | W | 62-74 | |
| 2021-01-27 | @ | Penn St. | W | 83-79 | |
| 2021-01-31 | @ | Michigan St. | W | 79-62 | |
| 2021-02-04 | vs. | Iowa | W | 85-89 | |
| 2021-02-08 | vs. | Maryland | W | 65-73 | |
| 2021-02-13 | @ | Indiana | W | 78-59 | |
| 2021-02-18 | vs. | Penn St. | W | 82-92 | |
| 2021-02-21 | @ | Michigan | L | 87-92 | |
| 2021-02-25 | vs. | Michigan St. | L | 71-67 | |
| 2021-02-28 | @ | Iowa | L | 57-73 | |
| 2021-03-06 | @ | Illinois | L | 68-73 | |
| 2021-03-11 | @ | Minnesota | W | 79-75 | |
| 2021-03-12 | vs. | Purdue | W | 78-87 | OT |
| 2021-03-14 | vs. | Illinois | L | 91-88 | OT |
| 2021-03-19 | @ | Oral Roberts | L | 72-75 | OT |