| 2020-11-25 | vs. | Chicago St. | W | 61-84 | |
| 2020-11-26 | @ | North Carolina A&T | W | 84-72 | |
| 2020-11-27 | vs. | Illinois | L | 77-75 | |
| 2020-12-06 | @ | Cleveland St. | W | 101-46 | |
| 2020-12-13 | vs. | Marshall | L | 81-67 | |
| 2020-12-22 | vs. | Akron | L | 90-70 | |
| 2020-12-30 | @ | Bowling Green | L | 75-83 | |
| 2021-01-02 | vs. | Ball St. | W | 68-78 | |
| 2021-01-05 | @ | Northern Ill. | W | 76-73 | |
| 2021-01-08 | vs. | Toledo | L | 95-78 | |
| 2021-01-12 | @ | Miami (OH) | W | 78-61 | |
| 2021-01-16 | @ | Kent St. | L | 79-89 | |
| 2021-01-23 | @ | Ball St. | W | 85-77 | |
| 2021-01-26 | @ | Western Mich. | W | 81-58 | |
| 2021-01-29 | vs. | Buffalo | W | 75-76 | |
| 2021-02-02 | vs. | Central Mich. | W | 69-83 | |
| 2021-02-23 | @ | Akron | W | 90-73 | |
| 2021-02-25 | @ | Eastern Mich. | W | 86-67 | |
| 2021-02-27 | @ | Buffalo | L | 66-86 | |
| 2021-03-11 | vs. | Kent St. | W | 63-85 | |
| 2021-03-12 | vs. | Toledo | W | 80-87 | |
| 2021-03-20 | vs. | Virginia | W | 58-62 | |
| 2021-03-22 | vs. | Creighton | L | 72-58 |