| 2020-11-28 | vs. | Michigan St. | L | 80-70 | |
| 2020-12-06 | @ | Detroit Mercy | W | 78-70 | |
| 2020-12-08 | @ | Ohio St. | L | 85-90 | |
| 2020-12-12 | vs. | Kentucky | W | 63-64 | |
| 2020-12-16 | @ | Duke | L | 65-75 | |
| 2020-12-19 | @ | Purdue | L | 78-88 | |
| 2020-12-23 | @ | Bellarmine | W | 81-70 | |
| 2020-12-30 | @ | Virginia | L | 57-66 | |
| 2021-01-02 | vs. | North Carolina | L | 66-65 | |
| 2021-01-10 | vs. | Virginia Tech | L | 77-63 | |
| 2021-01-13 | vs. | Virginia | L | 80-68 | |
| 2021-01-16 | @ | Boston College | W | 80-70 | |
| 2021-01-24 | vs. | Miami (FL) | W | 59-73 | |
| 2021-01-27 | @ | Virginia Tech | L | 51-62 | |
| 2021-01-30 | vs. | Pittsburgh | W | 58-84 | |
| 2021-02-02 | @ | Wake Forest | W | 79-58 | |
| 2021-02-06 | vs. | Georgia Tech | L | 82-80 | |
| 2021-02-09 | vs. | Duke | W | 89-93 | |
| 2021-02-14 | @ | Miami (FL) | W | 71-61 | |
| 2021-02-20 | vs. | Syracuse | L | 75-67 | |
| 2021-02-23 | vs. | Louisville | L | 69-57 | |
| 2021-02-27 | vs. | Boston College | L | 94-90 | |
| 2021-03-03 | @ | North Carolina St. | L | 69-80 | |
| 2021-03-06 | @ | Florida St. | W | 83-73 | |
| 2021-03-09 | @ | Wake Forest | W | 80-77 | |
| 2021-03-10 | vs. | North Carolina | L | 101-59 |