| 2020-11-28 | vs. | Michigan St. | L | 80-70 | |
| 2020-12-06 | @ | Detroit Mercy | W | 78-70 | |
| 2020-12-08 | @ | Ohio St. | L | 85-90 | |
| 2020-12-12 | vs. | Kentucky | W | 63-64 | |
| 2020-12-16 | @ | Duke | L | 65-75 | |
| 2020-12-19 | @ | Purdue | L | 78-88 | |
| 2020-12-30 | @ | Virginia | L | 57-66 | |
| 2021-01-02 | vs. | North Carolina | L | 66-65 | |
| 2021-01-10 | vs. | Virginia Tech | L | 77-63 | |
| 2021-01-13 | vs. | Virginia | L | 80-68 | |
| 2021-01-16 | @ | Boston College | W | 80-70 | |
| 2021-01-24 | vs. | Miami (FL) | W | 59-73 | |
| 2021-01-27 | @ | Virginia Tech | |||
| 2021-01-30 | vs. | Pittsburgh | |||
| 2021-02-02 | @ | Wake Forest | |||
| 2021-02-06 | vs. | Georgia Tech | |||
| 2021-02-09 | vs. | Duke |