| 2020-12-02 | @ | Ark.-Pine Bluff | W | 92-49 | |
| 2020-12-05 | @ | Chicago St. | W | 111-66 | |
| 2020-12-09 | @ | Pittsburgh | L | 70-71 | |
| 2020-12-20 | @ | Michigan St. | W | 79-65 | |
| 2020-12-23 | vs. | Indiana | W | 67-74 | |
| 2020-12-26 | @ | Ohio St. | W | 71-70 | |
| 2020-12-29 | vs. | Iowa | L | 87-72 | |
| 2021-01-03 | vs. | Michigan | L | 85-66 | |
| 2021-01-07 | @ | Illinois | L | 56-81 | |
| 2021-01-13 | vs. | Ohio St. | L | 81-71 | |
| 2021-01-17 | @ | Iowa | L | 73-96 | |
| 2021-01-20 | vs. | Wisconsin | L | 68-52 | |
| 2021-01-23 | vs. | Penn St. | L | 81-78 | |
| 2021-01-31 | @ | Rutgers | L | 56-64 | |
| 2021-02-06 | vs. | Purdue | L | 75-70 | |
| 2021-02-10 | @ | Indiana | L | 76-79 | 2OT |
| 2021-02-13 | vs. | Rutgers | L | 64-50 | |
| 2021-02-16 | vs. | Illinois | L | 73-66 | |
| 2021-02-21 | @ | Wisconsin | L | 51-68 | |
| 2021-02-25 | vs. | Minnesota | W | 59-67 | |
| 2021-03-03 | @ | Maryland | W | 60-55 | |
| 2021-03-07 | @ | Nebraska | W | 79-78 | |
| 2021-03-10 | @ | Minnesota | L | 46-51 |