| 2020-11-25 | @ | Ill.-Chicago | L | 61-65 | |
| 2020-12-02 | @ | SIUE | L | 53-73 | |
| 2020-12-05 | vs. | Pittsburgh | L | 89-59 | |
| 2020-12-08 | @ | Ball St. | L | 70-79 | OT |
| 2020-12-13 | vs. | Iowa | L | 106-53 | |
| 2020-12-18 | @ | Chicago St. | W | 64-54 | |
| 2020-12-22 | vs. | Toledo | L | 78-55 | |
| 2021-01-02 | @ | Bowling Green | L | 42-68 | |
| 2021-01-05 | vs. | Ohio | L | 76-73 | |
| 2021-01-09 | vs. | Miami (OH) | L | 70-58 | |
| 2021-01-12 | @ | Akron | W | 67-65 | |
| 2021-01-16 | vs. | Ball St. | L | 78-58 | |
| 2021-02-13 | vs. | Kent St. | L | 80-58 | |
| 2021-02-16 | vs. | Akron | L | 81-76 | |
| 2021-02-20 | @ | Miami (OH) | L | 64-69 | |
| 2021-02-23 | @ | Buffalo | L | 74-102 | |
| 2021-02-27 | vs. | Eastern Mich. | L | 91-57 | |
| 2021-03-02 | @ | Western Mich. | L | 63-73 | |
| 2021-03-05 | vs. | Central Mich. | W | 74-79 |