| 2020-11-26 | @ | Mississippi Val. | W | 116-62 | |
| 2020-11-28 | vs. | Arkansas | L | 69-54 | |
| 2020-12-04 | vs. | Mississippi St. | L | 69-63 | |
| 2020-12-11 | vs. | West Virginia | L | 62-50 | |
| 2020-12-15 | @ | Ark.-Pine Bluff | W | 81-56 | |
| 2020-12-17 | @ | Houston Baptist | W | 85-55 | |
| 2021-01-02 | vs. | Loyola Chicago | L | 57-49 | |
| 2021-01-08 | vs. | UTSA | W | 70-77 | |
| 2021-01-09 | vs. | UTSA | L | 77-69 | |
| 2021-01-15 | @ | UTEP | W | 63-33 | |
| 2021-01-16 | @ | UTEP | W | 74-65 | |
| 2021-01-29 | vs. | Rice | W | 74-79 | |
| 2021-01-31 | @ | Rice | W | 79-53 | |
| 2021-02-05 | @ | Louisiana Tech | L | 63-68 | |
| 2021-02-06 | @ | Louisiana Tech | W | 57-55 | |
| 2021-02-12 | vs. | Southern Miss. | W | 49-65 | |
| 2021-02-13 | vs. | Southern Miss. | W | 56-68 | |
| 2021-02-26 | vs. | Marshall | W | 65-77 | |
| 2021-02-27 | vs. | Marshall | L | 73-72 | |
| 2021-03-05 | @ | UAB | L | 51-65 | |
| 2021-03-06 | @ | UAB | L | 61-65 | |
| 2021-03-10 | @ | Middle Tenn. | W | 76-56 | |
| 2021-03-11 | vs. | Old Dominion | W | 55-61 | |
| 2021-03-12 | vs. | Louisiana Tech | W | 48-54 | |
| 2021-03-19 | vs. | Purdue | W | 69-78 | OT |
| 2021-03-21 | vs. | Villanova | L | 84-61 |