| 2020-11-25 | @ | Charleston So. | W | 95-61 | |
| 2020-11-27 | @ | North Florida | W | 86-51 | |
| 2020-12-03 | @ | UMass Lowell | W | 90-59 | |
| 2020-12-17 | vs. | Saint Louis | L | 80-69 | |
| 2020-12-19 | @ | Campbell | W | 69-50 | |
| 2020-12-22 | @ | North Carolina | W | 79-76 | |
| 2020-12-30 | @ | Boston College | W | 79-76 | |
| 2021-01-05 | vs. | Clemson | L | 74-70 | OT |
| 2021-01-09 | @ | Miami (FL) | L | 59-64 | |
| 2021-01-13 | vs. | Florida St. | L | 105-73 | |
| 2021-01-23 | vs. | North Carolina | L | 86-76 | |
| 2021-01-27 | @ | Wake Forest | W | 72-67 | |
| 2021-01-31 | vs. | Syracuse | L | 76-73 | |
| 2021-02-03 | @ | Virginia | L | 57-64 | |
| 2021-02-06 | vs. | Boston College | W | 65-81 | |
| 2021-02-09 | @ | Syracuse | L | 68-77 | |
| 2021-02-13 | @ | Duke | L | 53-69 | |
| 2021-02-17 | vs. | Pittsburgh | W | 73-74 | |
| 2021-02-20 | vs. | Wake Forest | W | 62-80 | |
| 2021-02-24 | vs. | Virginia | W | 61-68 | |
| 2021-02-28 | @ | Pittsburgh | W | 65-62 | |
| 2021-03-03 | vs. | Notre Dame | W | 69-80 | |
| 2021-03-10 | vs. | Syracuse | L | 89-68 | |
| 2021-03-18 | vs. | Davidson | W | 61-75 | |
| 2021-03-25 | vs. | Colorado St. | L | 65-61 |