| 2020-11-25 | @ | Col. of Charleston | W | 79-60 | |
| 2020-11-30 | vs. | UNLV | W | 51-78 | |
| 2020-12-01 | vs. | Stanford | W | 63-67 | |
| 2020-12-02 | @ | Texas | L | 67-69 | |
| 2020-12-08 | vs. | Iowa | L | 93-80 | |
| 2020-12-12 | @ | UNC Central | W | 73-67 | |
| 2020-12-19 | vs. | Kentucky | W | 63-75 | |
| 2020-12-22 | vs. | North Carolina St. | L | 79-76 | |
| 2020-12-30 | vs. | Georgia Tech | L | 72-67 | |
| 2021-01-02 | @ | Notre Dame | W | 66-65 | |
| 2021-01-05 | vs. | Miami (FL) | W | 65-67 | |
| 2021-01-12 | @ | Syracuse | W | 81-75 | |
| 2021-01-16 | vs. | Florida St. | L | 82-75 | |
| 2021-01-20 | @ | Wake Forest | W | 80-73 | |
| 2021-01-23 | @ | North Carolina St. | W | 86-76 | |
| 2021-01-26 | vs. | Pittsburgh | W | 65-75 | |
| 2021-02-02 | vs. | Clemson | L | 63-50 | |
| 2021-02-06 | vs. | Duke | W | 87-91 | |
| 2021-02-13 | vs. | Virginia | L | 60-48 | |
| 2021-02-17 | @ | Northeastern | W | 82-62 | |
| 2021-02-20 | @ | Louisville | W | 99-54 | |
| 2021-02-24 | @ | Marquette | L | 70-83 | |
| 2021-02-27 | @ | Florida St. | W | 78-70 | |
| 2021-03-01 | vs. | Syracuse | L | 72-70 | |
| 2021-03-06 | @ | Duke | W | 91-73 | |
| 2021-03-10 | @ | Notre Dame | W | 101-59 | |
| 2021-03-11 | vs. | Virginia Tech | W | 73-81 | |
| 2021-03-12 | vs. | Florida St. | L | 69-66 | |
| 2021-03-19 | @ | Wisconsin | L | 62-85 |