| 2020-11-25 | @ | McNeese | W | 102-55 | |
| 2020-11-26 | @ | Nevada | L | 66-69 | |
| 2020-11-28 | @ | North Dakota St. | W | 79-57 | |
| 2020-12-01 | @ | South Dakota | W | 76-69 | |
| 2020-12-09 | @ | Georgia Tech | L | 64-75 | |
| 2020-12-11 | vs. | Creighton | L | 98-74 | |
| 2020-12-22 | vs. | Wisconsin | L | 67-53 | |
| 2020-12-25 | @ | Michigan | L | 69-80 | |
| 2020-12-30 | vs. | Ohio St. | L | 90-54 | |
| 2021-01-02 | @ | Michigan St. | L | 77-84 | |
| 2021-01-10 | @ | Indiana | L | 76-84 | |
| 2021-01-13 | @ | Illinois | |||
| 2021-01-16 | vs. | Maryland | |||
| 2021-01-20 | @ | Minnesota | |||
| 2021-01-24 | vs. | Iowa | |||
| 2021-01-30 | @ | Penn St. | |||
| 2021-02-06 | vs. | Michigan St. | |||
| 2021-02-08 | vs. | Minnesota | |||
| 2021-02-11 | @ | Wisconsin |