| 2020-11-25 | @ | McNeese | W | 102-55 | |
| 2020-11-26 | @ | Nevada | L | 66-69 | |
| 2020-11-28 | @ | North Dakota St. | W | 79-57 | |
| 2020-12-01 | @ | South Dakota | W | 76-69 | |
| 2020-12-09 | @ | Georgia Tech | L | 64-75 | |
| 2020-12-11 | vs. | Creighton | L | 98-74 | |
| 2020-12-22 | vs. | Wisconsin | L | 67-53 | |
| 2020-12-25 | @ | Michigan | L | 69-80 | |
| 2020-12-30 | vs. | Ohio St. | L | 90-54 | |
| 2021-01-02 | @ | Michigan St. | L | 77-84 | |
| 2021-01-10 | @ | Indiana | L | 76-84 | |
| 2021-02-06 | vs. | Michigan St. | L | 66-56 | |
| 2021-02-08 | vs. | Minnesota | L | 79-61 | |
| 2021-02-10 | @ | Wisconsin | L | 48-61 | |
| 2021-02-12 | @ | Illinois | L | 72-77 | OT |
| 2021-02-14 | vs. | Penn St. | W | 61-62 | |
| 2021-02-16 | vs. | Maryland | L | 64-50 | |
| 2021-02-17 | vs. | Maryland | L | 79-71 | |
| 2021-02-20 | @ | Purdue | L | 58-75 | |
| 2021-02-23 | @ | Penn St. | L | 83-86 | |
| 2021-02-25 | vs. | Illinois | L | 86-70 | |
| 2021-02-27 | @ | Minnesota | W | 78-74 | |
| 2021-03-01 | @ | Rutgers | W | 72-51 | |
| 2021-03-04 | vs. | Iowa | L | 102-64 | |
| 2021-03-07 | vs. | Northwestern | L | 79-78 | |
| 2021-03-10 | vs. | Penn St. | L | 72-66 |