| 2020-12-02 | vs. | Middle Tenn. | L | 78-61 | |
| 2020-12-05 | @ | Illinois St. | W | 76-65 | |
| 2020-12-08 | @ | Austin Peay | W | 87-57 | |
| 2020-12-11 | vs. | Southern Ill. | L | 70-66 | |
| 2020-12-21 | vs. | Austin Peay | L | 74-70 | |
| 2020-12-30 | vs. | Belmont | L | 68-55 | |
| 2021-01-02 | @ | Morehead St. | L | 56-61 | |
| 2021-01-07 | vs. | Eastern Ill. | L | 74-68 | |
| 2021-01-16 | vs. | UT Martin | W | 57-79 | |
| 2021-01-21 | @ | Jacksonville St. | L | 82-85 | |
| 2021-01-23 | @ | Tennessee Tech | W | 72-63 | |
| 2021-01-28 | @ | Tennessee St. | W | 73-53 | |
| 2021-01-30 | @ | Belmont | L | 71-72 | |
| 2021-02-01 | vs. | Southeast Mo. St. | W | 60-77 | |
| 2021-02-04 | vs. | Morehead St. | L | 66-56 | |
| 2021-02-06 | vs. | Eastern Ky. | W | 64-76 | |
| 2021-02-12 | @ | Southeast Mo. St. | W | 80-60 | |
| 2021-02-13 | @ | UT Martin | W | 84-55 | |
| 2021-02-15 | vs. | SIUE | W | 57-86 | |
| 2021-02-18 | @ | Eastern Ill. | L | 59-68 | |
| 2021-02-20 | @ | SIUE | W | 89-62 | |
| 2021-02-25 | vs. | Jacksonville St. | L | 87-74 | |
| 2021-02-27 | vs. | Tennessee Tech | L | 71-61 | |
| 2021-03-04 | vs. | Jacksonville St. | L | 68-65 | OT |