| 2020-11-25 | vs. | Kentucky | L | 81-45 | |
| 2020-11-27 | vs. | Richmond | L | 82-64 | |
| 2020-11-29 | @ | Arkansas St. | W | 69-61 | |
| 2020-12-02 | vs. | Ohio St. | L | 77-44 | |
| 2020-12-07 | vs. | Eastern Ky. | L | 71-68 | |
| 2020-12-14 | @ | Eastern Ky. | W | 75-62 | |
| 2020-12-18 | @ | SIUE | L | 65-69 | |
| 2020-12-21 | vs. | Clemson | L | 66-51 | |
| 2021-01-02 | vs. | Murray St. | W | 56-61 | |
| 2021-01-07 | @ | Tennessee Tech | W | 57-54 | |
| 2021-01-09 | @ | Jacksonville St. | W | 56-55 | |
| 2021-01-14 | vs. | Eastern Ill. | W | 61-87 | |
| 2021-01-16 | vs. | Southeast Mo. St. | W | 50-64 | |
| 2021-01-21 | @ | Southeast Mo. St. | W | 76-65 | |
| 2021-01-23 | @ | UT Martin | W | 76-44 | |
| 2021-01-28 | vs. | Jacksonville St. | W | 66-85 | |
| 2021-01-30 | vs. | Tennessee Tech | W | 55-74 | |
| 2021-02-04 | @ | Murray St. | W | 66-56 | |
| 2021-02-06 | @ | Austin Peay | W | 75-74 | OT |
| 2021-02-11 | vs. | Tennessee St. | W | 66-79 | |
| 2021-02-13 | vs. | Belmont | L | 73-58 | |
| 2021-02-20 | vs. | UT Martin | W | 69-79 | |
| 2021-02-22 | vs. | SIUE | W | 48-56 | |
| 2021-02-25 | @ | Tennessee St. | W | 74-60 | |
| 2021-02-27 | @ | Belmont | W | 89-82 | OT |
| 2021-03-03 | @ | Southeast Mo. St. | W | 61-54 | |
| 2021-03-05 | @ | Eastern Ky. | W | 67-64 | |
| 2021-03-06 | vs. | Belmont | W | 71-86 | |
| 2021-03-19 | vs. | West Virginia | L | 84-67 |