| 2020-11-25 | vs. | Arkansas | L | 142-62 | |
| 2020-11-26 | vs. | North Texas | L | 116-62 | |
| 2020-11-28 | vs. | Wyoming | L | 97-61 | |
| 2020-12-01 | vs. | Grand Canyon | L | 88-49 | |
| 2020-12-06 | vs. | Western Ky. | L | 96-69 | |
| 2020-12-08 | vs. | Memphis | L | 94-57 | |
| 2020-12-13 | vs. | Vanderbilt | L | 84-41 | |
| 2020-12-21 | vs. | Mississippi St. | L | 87-48 | |
| 2021-01-02 | vs. | Ark.-Pine Bluff | L | 92-52 | |
| 2021-01-12 | @ | Alabama St. | L | 51-64 | |
| 2021-01-16 | vs. | Alcorn | L | 71-59 | |
| 2021-01-18 | vs. | Southern U. | L | 102-61 | |
| 2021-01-23 | @ | Prairie View | L | 31-77 | |
| 2021-01-30 | vs. | Jackson St. | L | 106-56 | |
| 2021-02-01 | vs. | Grambling | L | 85-72 | |
| 2021-02-06 | vs. | Alabama A&M | L | 93-58 | |
| 2021-02-08 | vs. | Alabama St. | W | 65-68 | |
| 2021-02-13 | @ | Alcorn | L | 56-70 | |
| 2021-02-23 | vs. | Texas Southern | L | 82-45 | |
| 2021-02-25 | vs. | Prairie View | L | 82-62 | |
| 2021-02-27 | @ | Jackson St. | L | 54-68 | |
| 2021-03-01 | @ | Grambling | W | 67-63 | |
| 2021-03-05 | @ | Ark.-Pine Bluff | L | 59-82 | |
| 2021-03-10 | vs. | Prairie View | L | 91-64 |