| 2020-11-25 | @ | Eastern Mich. | W | 83-67 | |
| 2020-11-28 | @ | Notre Dame | W | 80-70 | |
| 2020-12-01 | vs. | Duke | W | 69-75 | |
| 2020-12-04 | @ | Detroit Mercy | W | 83-76 | |
| 2020-12-06 | @ | Western Mich. | W | 79-61 | |
| 2020-12-13 | @ | Oakland | W | 109-91 | |
| 2020-12-20 | vs. | Northwestern | L | 79-65 | |
| 2020-12-25 | @ | Wisconsin | L | 76-85 | |
| 2020-12-28 | vs. | Minnesota | L | 81-56 | |
| 2021-01-02 | vs. | Nebraska | W | 77-84 | |
| 2021-01-05 | @ | Rutgers | W | 68-45 | |
| 2021-01-08 | @ | Purdue | L | 54-55 | |
| 2021-01-28 | vs. | Rutgers | L | 67-37 | |
| 2021-01-31 | vs. | Ohio St. | L | 79-62 | |
| 2021-02-02 | vs. | Iowa | L | 84-78 | |
| 2021-02-06 | @ | Nebraska | W | 66-56 | |
| 2021-02-09 | @ | Penn St. | W | 60-58 | |
| 2021-02-13 | @ | Iowa | L | 58-88 | |
| 2021-02-16 | vs. | Purdue | L | 75-65 | |
| 2021-02-20 | vs. | Indiana | W | 71-78 | |
| 2021-02-23 | @ | Illinois | W | 81-72 | |
| 2021-02-25 | @ | Ohio St. | W | 71-67 | |
| 2021-02-28 | vs. | Maryland | L | 73-55 | |
| 2021-03-02 | @ | Indiana | W | 64-58 | |
| 2021-03-04 | vs. | Michigan | L | 69-50 | |
| 2021-03-07 | @ | Michigan | W | 70-64 | |
| 2021-03-11 | vs. | Maryland | L | 68-57 | |
| 2021-03-18 | @ | UCLA | L | 80-86 | OT |