| 2020-11-25 | @ | Bowling Green | W | 96-82 | |
| 2020-11-29 | @ | Oakland | W | 81-71 | OT |
| 2020-12-02 | @ | Ball St. | W | 84-65 | |
| 2020-12-06 | @ | UCF | W | 80-58 | |
| 2020-12-09 | @ | Toledo | W | 91-71 | |
| 2020-12-13 | @ | Penn St. | W | 62-58 | |
| 2020-12-25 | vs. | Nebraska | W | 69-80 | |
| 2020-12-31 | vs. | Maryland | W | 73-84 | |
| 2021-01-03 | @ | Northwestern | W | 85-66 | |
| 2021-01-06 | @ | Minnesota | W | 82-57 | |
| 2021-01-12 | @ | Wisconsin | W | 77-54 | |
| 2021-01-16 | vs. | Minnesota | L | 75-57 | |
| 2021-01-19 | @ | Maryland | W | 87-63 | |
| 2021-01-22 | vs. | Purdue | W | 53-70 | |
| 2021-01-27 | vs. | Penn St. | |||
| 2021-01-30 | @ | Indiana | |||
| 2021-02-03 | vs. | Northwestern | |||
| 2021-02-06 | @ | Michigan St. | |||
| 2021-02-11 | @ | Illinois |