| 2020-11-25 | @ | Bowling Green | W | 96-82 | |
| 2020-11-29 | @ | Oakland | W | 81-71 | OT |
| 2020-12-02 | @ | Ball St. | W | 84-65 | |
| 2020-12-06 | @ | UCF | W | 80-58 | |
| 2020-12-09 | @ | Toledo | W | 91-71 | |
| 2020-12-13 | @ | Penn St. | W | 62-58 | |
| 2020-12-25 | vs. | Nebraska | W | 69-80 | |
| 2020-12-31 | vs. | Maryland | W | 73-84 | |
| 2021-01-03 | @ | Northwestern | W | 85-66 | |
| 2021-01-06 | @ | Minnesota | W | 82-57 | |
| 2021-01-12 | @ | Wisconsin | W | 77-54 | |
| 2021-01-16 | vs. | Minnesota | L | 75-57 | |
| 2021-01-19 | @ | Maryland | W | 87-63 | |
| 2021-01-22 | vs. | Purdue | W | 53-70 | |
| 2021-02-14 | vs. | Wisconsin | W | 59-67 | |
| 2021-02-18 | @ | Rutgers | W | 71-64 | |
| 2021-02-21 | vs. | Ohio St. | W | 87-92 | |
| 2021-02-25 | @ | Iowa | W | 79-57 | |
| 2021-02-27 | vs. | Indiana | W | 57-73 | |
| 2021-03-02 | @ | Illinois | L | 53-76 | |
| 2021-03-04 | @ | Michigan St. | W | 69-50 | |
| 2021-03-07 | vs. | Michigan St. | L | 70-64 | |
| 2021-03-12 | @ | Maryland | W | 79-66 | |
| 2021-03-20 | @ | Texas Southern | W | 82-66 | |
| 2021-03-22 | @ | LSU | W | 86-78 | |
| 2021-03-28 | @ | Florida St. | W | 76-58 | |
| 2021-03-30 | @ | UCLA | L | 49-51 |