| 2020-11-25 | @ | Old Dominion | W | 85-67 | |
| 2020-11-27 | @ | Navy | W | 82-52 | |
| 2020-11-29 | @ | Mt. St. Mary's | W | 79-61 | |
| 2020-12-04 | @ | Saint Peter's | W | 90-57 | |
| 2020-12-09 | vs. | Clemson | L | 67-51 | |
| 2020-12-14 | @ | Rutgers | L | 60-74 | |
| 2020-12-22 | @ | La Salle | W | 84-71 | |
| 2020-12-25 | vs. | Purdue | L | 73-70 | |
| 2020-12-28 | vs. | Wisconsin | W | 64-70 | |
| 2020-12-31 | @ | Michigan | L | 73-84 | |
| 2021-01-04 | vs. | Indiana | L | 63-55 | |
| 2021-01-07 | @ | Iowa | L | 67-89 | |
| 2021-01-10 | vs. | Illinois | W | 63-66 | |
| 2021-01-19 | vs. | Michigan | L | 87-63 | |
| 2021-01-23 | vs. | Minnesota | W | 49-63 | |
| 2021-01-27 | @ | Wisconsin | L | 55-61 | |
| 2021-02-02 | @ | Purdue | W | 61-60 | |
| 2021-02-05 | vs. | Penn St. | L | 55-50 | |
| 2021-02-08 | @ | Ohio St. | L | 65-73 | |
| 2021-02-14 | @ | Minnesota | W | 72-59 | |
| 2021-02-16 | @ | Nebraska | W | 64-50 | |
| 2021-02-17 | @ | Nebraska | W | 79-71 | |
| 2021-02-21 | vs. | Rutgers | W | 59-68 | |
| 2021-02-28 | @ | Michigan St. | W | 73-55 | |
| 2021-03-03 | vs. | Northwestern | L | 60-55 | |
| 2021-03-07 | @ | Penn St. | L | 61-66 | |
| 2021-03-11 | @ | Michigan St. | W | 68-57 | |
| 2021-03-12 | vs. | Michigan | L | 79-66 | |
| 2021-03-20 | vs. | UConn | W | 54-63 | |
| 2021-03-22 | vs. | Alabama | L | 96-77 |