| 2020-11-25 | @ | Ark.-Pine Bluff | W | 99-57 | |
| 2020-11-27 | @ | Eastern Ill. | W | 75-50 | |
| 2020-12-01 | @ | Oklahoma St. | L | 62-70 | |
| 2020-12-04 | @ | Wisconsin | W | 67-65 | |
| 2020-12-08 | @ | Green Bay | W | 82-68 | |
| 2020-12-11 | vs. | UCLA | L | 69-60 | |
| 2020-12-14 | vs. | Creighton | W | 84-89 | |
| 2020-12-17 | @ | Seton Hall | L | 63-70 | |
| 2020-12-20 | vs. | Xavier | L | 91-88 | |
| 2020-12-23 | @ | Villanova | L | 68-85 | |
| 2021-01-02 | vs. | Georgetown | W | 60-64 | |
| 2021-01-05 | @ | UConn | L | 54-65 | |
| 2021-01-12 | @ | Providence | W | 79-69 | |
| 2021-01-16 | vs. | St. John's (NY) | W | 71-73 | |
| 2021-01-23 | @ | DePaul | L | 61-68 | |
| 2021-01-27 | vs. | Providence | L | 72-63 | OT |
| 2021-01-31 | @ | St. John's (NY) | L | 73-75 | |
| 2021-02-02 | @ | Butler | W | 70-67 | |
| 2021-02-06 | @ | Creighton | L | 68-71 | |
| 2021-02-10 | vs. | Villanova | L | 96-64 | |
| 2021-02-14 | vs. | Seton Hall | L | 57-51 | |
| 2021-02-17 | vs. | Butler | W | 57-73 | |
| 2021-02-24 | vs. | North Carolina | W | 70-83 | |
| 2021-02-27 | vs. | UConn | L | 80-62 | |
| 2021-03-02 | vs. | DePaul | W | 71-77 | |
| 2021-03-06 | @ | Xavier | W | 66-59 | |
| 2021-03-10 | vs. | Georgetown | L | 68-49 |