| 2020-12-09 | @ | Chicago St. | W | 88-51 | |
| 2020-12-13 | vs. | Ill.-Chicago | W | 66-77 | |
| 2020-12-15 | vs. | Wisconsin | L | 77-63 | |
| 2020-12-18 | vs. | Richmond | L | 75-73 | |
| 2020-12-27 | @ | Illinois St. | W | 90-60 | |
| 2020-12-28 | @ | Illinois St. | W | 86-55 | |
| 2021-01-02 | @ | North Texas | W | 57-49 | |
| 2021-01-10 | vs. | Indiana St. | L | 76-71 | |
| 2021-01-11 | vs. | Indiana St. | W | 48-58 | |
| 2021-01-16 | @ | UNI | W | 72-57 | |
| 2021-01-17 | @ | UNI | W | 88-46 | |
| 2021-01-20 | vs. | Valparaiso | W | 39-75 | |
| 2021-01-24 | vs. | Bradley | W | 56-69 | |
| 2021-01-25 | vs. | Bradley | W | 58-65 | |
| 2021-01-31 | vs. | Missouri St. | W | 46-72 | |
| 2021-02-01 | vs. | Missouri St. | W | 50-70 | |
| 2021-02-06 | @ | Evansville | W | 68-55 | |
| 2021-02-07 | @ | Evansville | W | 69-58 | |
| 2021-02-13 | vs. | Drake | W | 54-81 | |
| 2021-02-14 | vs. | Drake | L | 51-50 | OT |
| 2021-02-17 | @ | Valparaiso | W | 54-52 | |
| 2021-02-26 | @ | Southern Ill. | W | 60-52 | |
| 2021-02-27 | @ | Southern Ill. | W | 65-58 | OT |
| 2021-03-05 | @ | Southern Ill. | W | 73-49 | |
| 2021-03-06 | @ | Indiana St. | W | 65-49 | |
| 2021-03-07 | @ | Drake | W | 75-65 | |
| 2021-03-19 | @ | Georgia Tech | W | 71-60 | |
| 2021-03-21 | vs. | Illinois | W | 58-71 | |
| 2021-03-27 | @ | Oregon St. | L | 58-65 |