| 2020-11-25 | @ | Evansville | W | 79-44 | |
| 2020-11-27 | @ | Seton Hall | W | 71-70 | |
| 2020-11-29 | @ | Prairie View | W | 86-64 | |
| 2020-12-01 | @ | Western Ky. | W | 75-54 | |
| 2020-12-19 | vs. | Wisconsin | L | 85-48 | |
| 2020-12-22 | vs. | Pittsburgh | W | 54-64 | |
| 2020-12-26 | @ | Kentucky | W | 62-59 | |
| 2021-01-02 | vs. | Boston College | W | 64-76 | |
| 2021-01-06 | @ | Virginia Tech | W | 73-71 | |
| 2021-01-13 | vs. | Wake Forest | W | 65-77 | |
| 2021-01-16 | vs. | Miami (FL) | L | 78-72 | |
| 2021-01-18 | @ | Florida St. | |||
| 2021-01-23 | @ | Duke | |||
| 2021-01-30 | @ | Boston College | |||
| 2021-02-03 | vs. | Syracuse | |||
| 2021-02-06 | vs. | Virginia | |||
| 2021-02-10 | @ | Pittsburgh |