| 2020-11-25 | @ | Evansville | W | 79-44 | |
| 2020-11-27 | @ | Seton Hall | W | 71-70 | |
| 2020-11-29 | @ | Prairie View | W | 86-64 | |
| 2020-12-01 | @ | Western Ky. | W | 75-54 | |
| 2020-12-19 | vs. | Wisconsin | L | 85-48 | |
| 2020-12-22 | vs. | Pittsburgh | W | 54-64 | |
| 2020-12-26 | @ | Kentucky | W | 62-59 | |
| 2021-01-02 | vs. | Boston College | W | 64-76 | |
| 2021-01-06 | @ | Virginia Tech | W | 73-71 | |
| 2021-01-13 | vs. | Wake Forest | W | 65-77 | |
| 2021-01-16 | vs. | Miami (FL) | L | 78-72 | |
| 2021-01-18 | @ | Florida St. | L | 65-78 | |
| 2021-01-23 | @ | Duke | W | 70-65 | |
| 2021-01-27 | vs. | Clemson | L | 54-50 | |
| 2021-02-01 | @ | Georgia Tech | W | 74-58 | |
| 2021-02-20 | vs. | North Carolina | L | 99-54 | |
| 2021-02-23 | @ | Notre Dame | W | 69-57 | |
| 2021-02-27 | vs. | Duke | W | 73-80 | OT |
| 2021-03-06 | @ | Virginia | L | 58-68 | |
| 2021-03-10 | @ | Duke | L | 56-70 |